2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Dihydroorotate Dehydrogenase DNA/RNA Synthesis
  4. hDHODH-IN-12

hDHODH-IN-12 是一种有效的 DHODH 抑制剂，其 IC50 值为0.421 μM。DHODH 是嘧啶从头合成的限速酶，对 RNA 和 DNA 的生成 (DNA/RNA Synthesis) 至关重要。hDHODH-IN-12 存在于人类线粒体的内膜中。hDHODH-IN-12 具有研究肺癌的潜力。

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hDHODH-IN-12 Chemical Structure

hDHODH-IN-12 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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hDHODH-IN-12 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hDHODH-IN-12 is a potent DHODH inhibitor with an IC50 value of 0.421 μM. DHODH is the rate-limiting enzyme in the de novo synthesis of pyrimidine which is essential in DNA/RNA Synthesis. hDHODH-IN-12 is present in the inner membrane of human mitochondria.hDHODH-IN-12 can be used for the research of lung cancer[1].

IC50 & Target

IC50: 0.421 μM (DHODH)[1]
体外研究
(In Vitro)

hDHODH-IN-12 (compound 5c) (100 μM; 24 h) 对 A549， H1299 和 H1975 细胞系的 TC50 值为 11μM, 11μM, 15μM[1]。 hDHODH-IN-12 (compound 5c) (100 μM; 24 h) 在 A549， H1299 和 H1975 细胞系中降低细胞活力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

hDHODH-IN-12 相关抗体:

Cell Viability Assay[1]

Cell Line: A549, H1299, and H1975 cells
Concentration: 100 μM
Incubation Time: 24 h
Result: Reduced cell viability by more than 50%.
分子量

440.37

Formula

C22H15F3N4O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

hDHODH-IN-12 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hDHODH-IN-12Dihydroorotate DehydrogenaseDNA/RNA SynthesisDHODHDihydroorotateDehydrogenasepyrimidinebiosynthesisA549H1299H1975cancerInhibitorinhibitorinhibit

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