2. Anti-infection
  3. Fungal
  4. Hecogenin

Hecogenin 是从剑麻 (Agave sisalana) 分离的类固醇皂苷，是人 UDP-葡萄糖醛酸糖基转移酶的选择性抑制剂。Hecogenin 具有广泛的药理活性，包括抗炎，抗真菌和胃保护作用。

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Hecogenin Chemical Structure

Hecogenin Chemical Structure

CAS No. : 467-55-0

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规格 价格 是否有货 数量
5 mg ￥171
In-stock
10 mg ￥246
In-stock
25 mg ￥433
In-stock
50 mg ￥621
In-stock
100 mg ￥915
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Other Forms of Hecogenin:

Hecogenin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects[1].

IC50 & Target

Human UDP-glucuronosyltransferases[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 40 μM
Compound: Hecogenin
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 33735799]
BT-474 IC50
38.2 μM
Compound: 1
Antiproliferative activity against human BT474 cells after 72 hrs by MTT assay
Antiproliferative activity against human BT474 cells after 72 hrs by MTT assay
[PMID: 29066046]
HT-29 IC50
> 40 μM
Compound: Hecogenin
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 33735799]
HUVEC IC50
> 100 μM
Compound: Hecogenin
Cytotoxicity against human HUVEC cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HUVEC cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 33735799]
MCF7 IC50
28.7 μM
Compound: Hecogenin
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 33735799]
MCF7 IC50
31 μM
Compound: 1
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 29066046]
MDA-MB-231 IC50
28.7 μM
Compound: 1
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 29066046]
MDA-MB-231 IC50
31.21 μM
Compound: Hecogenin
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 33735799]
MDA-MB-231 IC50
37.1 μM
Compound: 1
Antiinvasive activity against human MDA-MB-231 cells after 24 hrs by cell invasion assay
Antiinvasive activity against human MDA-MB-231 cells after 24 hrs by cell invasion assay
[PMID: 29066046]
MDA-MB-468 IC50
35.2 μM
Compound: 1
Antiproliferative activity against human MDA-MB-468 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-468 cells after 72 hrs by MTT assay
[PMID: 29066046]
SK-BR-3 IC50
33.3 μM
Compound: 1
Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT assay
Antiproliferative activity against human SKBR3 cells after 72 hrs by MTT assay
[PMID: 29066046]
T47D IC50
36.6 μM
Compound: 1
Antiproliferative activity against human T47D cells after 72 hrs by MTT assay
Antiproliferative activity against human T47D cells after 72 hrs by MTT assay
[PMID: 29066046]
体内研究
(In Vivo)

Hecogenin (3.1-90 mg/kg；口服给药；15 小时；雄性瑞士小鼠) 在乙醇之前急性给药，表现出强大的胃保护作用。Hecogenin 预处理使 GSH 水平正常化并显著降低胃中的脂质过氧化和亚硝酸盐水平，正如乙醇诱导的胃损伤模型所评估的那样。Hecogenin 还可以减少 MPO 释放并显著保护胃粘膜[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss mice (20-30 g) with ethanol[1]
Dosage: 3.1 mg/kg, 7.5 mg/kg, 15 mg/kg, 30 mg/kg, 60 mg/kg and 90 mg/kg
Administration: Oral administration; for 15 hours
Result: Normalized GSH levels and significantly reduced lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Decreased MPO release and significantly protected the gastric mucosa.
分子量

430.62

Formula

C27H42O4
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMF 中的溶解度 : 16.67 mg/mL (38.71 mM; 超声助溶 (<60°C))

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3222 mL 11.6112 mL 23.2223 mL
5 mM 0.4644 mL 2.3222 mL 4.6445 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.85%

COA (289 KB) RP-HPLC (217 KB)

产品使用指南 (1538 KB)
参考文献

Hecogenin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 2.3222 mL 11.6112 mL 23.2223 mL 58.0558 mL
5 mM 0.4644 mL 2.3222 mL 4.6445 mL 11.6112 mL
10 mM 0.2322 mL 1.1611 mL 2.3222 mL 5.8056 mL
15 mM 0.1548 mL 0.7741 mL 1.5482 mL 3.8704 mL
20 mM 0.1161 mL 0.5806 mL 1.1611 mL 2.9028 mL
25 mM 0.0929 mL 0.4644 mL 0.9289 mL 2.3222 mL
30 mM 0.0774 mL 0.3870 mL 0.7741 mL 1.9352 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hecogenin467-55-0FungalInhibitorinhibitorinhibit

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目录号：
HY-N1422
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