2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis Bacterial Topoisomerase
  4. Heliquinomycin

Heliquinomycin 是DNA 解旋酶 (DNA helicase) 的抑制剂 (Ki: 6.8 μM)，可抑制 DNA 和 RNA 的合成。Heliquinomycin 对革兰氏阳性细菌菌株具有有效的抗菌活性。Heliquinomycin 可抑制癌细胞生长。

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Heliquinomycin Chemical Structure

Heliquinomycin Chemical Structure

CAS No. : 178182-49-5

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Heliquinomycin 相关抗体

Top Publications Citing Use of Products

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth[1][2].

IC50 & Target[2]

Topoisomerase I

 

Topoisomerase II

 

体外研究
(In Vitro)

Heliquinomycin (18 h) 对革兰氏阳性菌株表现出很强的抑制活性，MIC 值为 0.1-0.39 μM[1]。
Heliquinomycin 抑制 HeLa S3、LI210 白血病、IMC、癌、B16 黑色素瘤细胞的生长，IC50s 为 0-1.6 μg/mL[1]。
Heliquinomycin (30 和 100 μg/mL) 抑制拓扑异构酶 II 和 I 酶活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Heliquinomycin 相关抗体:
体内研究
(In Vivo)

Heliquinomycin (100 mg/kg, i.p.) 对小鼠没有任何毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

698.58

Formula

C33H30O17
CAS 号
初始来源

Streptomyces sp. MJ929-SF2.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Heliquinomycin 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Heliquinomycin178182-49-5DNA/RNA SynthesisBacterialTopoisomeraseGram-positivecancerDNS synthesisbacteriatopoisomeraseInhibitorinhibitorinhibit

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