2. Metabolic Enzyme/Protease Apoptosis
  3. Thrombin Apoptosis
  4. Hirudin

Hirudin  (Synonyms: 水蛭素)

目录号: HY-P2813 纯度: ≥95.0%
COA 产品使用指南

摩尔计算器

Hirudin 是一种具有抗凝血特性的凝血酶抑制剂。Hirudin 具有较强的抗血栓、伤口修复、抗纤维化、抗肿瘤和抗高尿酸血症作用。Hirudin 还会影响糖尿病并发症、脑出血等。

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Custom Peptide Synthesis

Hirudin Chemical Structure

Hirudin Chemical Structure

CAS No. : 8001-27-2

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规格 价格 是否有货 数量
500 μg ￥6750
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Other Forms of Hirudin:

Hirudin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others[1].

体外研究
(In Vitro)

Hirudin 抑制凝血酶活性，剥夺凝血酶裂解纤维蛋白原的能力，阻止纤维蛋白的形成及内外凝血通路中纤维蛋白单体的交联聚合过程[1]。
Hirudin 通过拮抗凝血酶，减少人微血管内皮细胞凋亡，抑制 p-JAK2 的表达[1]。
Hirudin 抑制 VEGF-Notch 通路和人微血管内皮细胞增殖在高剂量时[1]。
Hirudin (3-10 mg/mL) 可逆转 TGF-β1 引起的 HK-2 细胞异常增殖和纤维化[1]。
Hirudin 剂量依赖性地抑制血管紧张素 II 诱导的心肌成纤维细胞，抑制氧化应激，调节纤维相关因子，抑制 ERK1/2 通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hirudin 相关抗体:
体内研究
(In Vivo)

Hirudin 增加大鼠随机皮瓣的生存能力，减少炎症反应[1]。
Hirudin 促进激光手术后 SD 大鼠的创面愈合[1]。
Hirudin (10 和 15 mg/kg；灌胃，每天 1 次，持续 21 天) 改善肾间质纤维化来减少肾小管损伤和炎症在单侧输尿管梗阻 (UUO) 小鼠模型中[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male balb/c mice with underwent unilateral ureteral ligation (UUO)[2]
Dosage: 10 and 15 mg/kg
Administration: Oral gavage; 10 and 15 mg/kg, once daily for 21 days
Result: Reduced renal damages and suppressed the upregulation of α-SMA, collagen deposition in UUO mice. Increased the level of fibrosis (collagen-I, FN, α-SMA), N-cad, slug and E-cad in UUO mice. Decreased the level of IL-1β, IL-6 and TNF-α, apoptosis of renal tubular cells in UUO mice. Decreased the expression of inflammatory factors, the occurrence of EMT, the incidence of fibrosis and the apoptosis of TGF-β-induced renal tubular epithelial cell.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

结构分类
初始来源

leech
运输条件

Shipping with dry ice.
储存方式

-80°C
纯度 & 产品资料

纯度: ≥95.0%

COA (254 KB)

产品使用指南 (1538 KB)
参考文献

Hirudin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hirudin8001-27-2ThrombinApoptosisanticoagulantanti-thromboticJAK2HMVECVEGFHK-2ERK1/2angiotensin IIUOOratInhibitorinhibitorinhibit

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