2. Anti-infection
  3. HIV
  4. HIV-1 inhibitor-24

HIV-1 inhibitor-24 (compound S-12a) 是一种高效的 HIV-1 逆转录 (HIV-1 RT) 抑制剂，IC50 为 9.5 nM。HIV-1 inhibitor-24对野生型 HIV-1具有较高的抗病毒活性 (EC50 = 1.6 nM)，且具有较低的细胞毒性 (MT-4 CC50 = 9.07 μM)。HIV-1 inhibitor-24 在小鼠中 2 g/kg 剂量下耐受良好，且具有显著的心血管安全性。

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HIV-1 inhibitor-24 Chemical Structure

HIV-1 inhibitor-24 Chemical Structure

CAS No. : 2475658-75-2

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HIV-1 inhibitor-24 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HIV-1 inhibitor-24 (compound S-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 9.5 nM. HIV-1 inhibitor-24 has high antiretroviral activity against WT HIV-1 with an EC50 of 1.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 9.07 μM in MT-4 cells. HIV-1 inhibitor-24 is well tolerated at a dose of 2 g/kg in mice and has a significant cardiovascular safety[1].

IC50 & Target[1]

HIV-1 (WT)

1.6 nM (EC50)

体内研究
(In Vivo)

HIV-1 inhibitor-24 (2 g/kg; IG; single dosage) is well tolerated at a dose of 2 g/kg in mice and has a significant cardiovascular safety[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[1]
Dosage: 2 g/kg
Administration: IG; single dosage
Result: Exhibited well tolerance at a dose of 2 g/kg in mice and a significant cardiovascular safety.
分子量

433.46

Formula

C26H19N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HIV-1 inhibitor-24 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 inhibitor-242475658-75-2HIVHuman immunodeficiency virusAnti-HIVAIDSReverse transcriptaseMT-4 cellsCardiovascular safetyInhibitorinhibitorinhibit

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HY-146019
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