2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. HP1328

HP1328 是 FLT3 受体酪氨酸激酶 (FLT3/ITD 突变) 的有效抑制剂。HP1328 是一种基于苯并咪唑支架的化合物。HP1328 显着降低白血病负担并延长 FLT3/ITD 白血病小鼠的生存期。

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HP1328 Chemical Structure

HP1328 Chemical Structure

CAS No. : 2245074-20-6

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HP1328 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HP1328 is a potent inhibitor of FLT3 receptor tyrosine kinase (FLT3/ITD mutation). HP1328 is a benzoimidazole scaffold-based compound. HP1328 significantly reduces the leukemia burden and prolongs the survival of mice with FLT3/ITD leukemia[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BaF3 IC50
> 0.4 μM
Compound: HP1328
Antiproliferative activity against mouse BaF3 cells expressing wild type FLT3 assessed as reduction in cell viability measured after 72 hrs by MTS assay
Antiproliferative activity against mouse BaF3 cells expressing wild type FLT3 assessed as reduction in cell viability measured after 72 hrs by MTS assay
[PMID: 35148084]
HL-60 IC50
> 50 μM
Compound: HP1328
Antiproliferative activity against human HL-60 cells expressing wild type FLT3 assessed as reduction in cell viability measured after 72 hrs by MTS assay
Antiproliferative activity against human HL-60 cells expressing wild type FLT3 assessed as reduction in cell viability measured after 72 hrs by MTS assay
[PMID: 35148084]
MOLM-13 IC50
66.8 nM
Compound: HP1328
Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as reduction in cell viability measured after 72 hrs by MTS assay
Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as reduction in cell viability measured after 72 hrs by MTS assay
[PMID: 35148084]
MV4-11 IC50
165 nM
Compound: HP1328
Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as reduction in cell viability measured after 72 hrs ny MTS assay
Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as reduction in cell viability measured after 72 hrs ny MTS assay
[PMID: 35148084]
分子量

389.45

Formula

C23H23N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HP1328 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HP13282245074-20-6HP 1328HP-1328FLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3tyrosine kinasebenzoimidazolescaffold-basedleukemiaInhibitorinhibitorinhibit

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产品名称：
HP1328
目录号：
HY-145690
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