2. Apoptosis Protein Tyrosine Kinase/RTK
  3. Apoptosis Bcr-Abl
  4. HS-438

HS-438 是一种强效且选择性的 BCR-ABL 抑制剂。HS-438 具有抗增殖活性。HS-438 可降低磷酸化的 BCR-ABL (Tyr177) 的表达。HS-438 可诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G0/G1 期。HS-438 具有抗肿瘤活性。HS-438 具有用于研究慢性粒细胞白血病 (CML) 的潜力。

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HS-438 Chemical Structure

HS-438 Chemical Structure

CAS No. : 1430720-10-7

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HS-438 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HS-438 is a potent and selective BCR-ABL inhibitor. HS-438 shows antiproliferative activity. HS-438 decreases the expression of phosphorylation of BCR-ABL (Tyr177). HS-438 induces apoptosis and cell cycle arrest at G0/G1 phase. HS-438 shows antitumor activity. HS-438 has the potential for the research of chronic myeloid leukemia (CML)[1].

分子量

343.40

Formula

C17H17N3O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HS-438 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HS-4381430720-10-7HS438HS 438ApoptosisBcr-Ablantiproliferativechronic myeloid leukemiaG0/G1 phaseapoptosisBaF3/T315I cellsBaF3/WT cellsInhibitorinhibitorinhibit

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