2. Epigenetics
  3. MicroRNA
  4. hsa-miR-4420 antagomir

hsa-miR-4420 antagomir 是一种经过特殊化学修饰的成熟miRNA的互补单链，全链进行甲氧基修饰，在5'端和3'端分别有2个和4个硫代骨架修饰，并在3'端连接有高亲和性胆固醇修饰。miRNA antagomir通过特异性结合成熟miRNA，阻止miRNA与其靶基因的互补配对，从而抑制miRNA的功能。相比于miRNA inhibitor，miRNA antagomir在动物实验中具有更高的稳定性和抑制效果，更易通过细胞膜、组织间隙而富集于靶细胞。

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RNA, (CUCAGCUACAGACAUCAGUG) (2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification)

hsa-miR-4420 antagomir Chemical Structure

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规格 价格 是否有货 数量
5 nmol ￥1580
1-2 weeks
20 nmol ￥3160
1-2 weeks

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Customer Review

Other Forms of hsa-miR-4420 antagomir:

hsa-miR-4420 antagomir 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

生物活性

hsa-miR-4420 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

分子量

7349.80

miRBase编号
成熟miRNA序列

GUCACUGAUGUCUGUAGCUGAG

茎环结构ID

hsa-mir-4420

茎环结构序列

CUCUUGGUAUGAACAUCUGUGUGUUCAUGUCUCUCUGUGCACAGGGGACGAGAGUCACUGAUGUCUGUAGCUGAGAC

种属

Human

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

hsa-miR-4420 antagomir 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hsa-miR-4420 antagomirMicroRNAmiRNAInhibitorinhibitorinhibit

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产品名称：
hsa-miR-4420 antagomir
目录号：
HY-RI01018A
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