2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. HSP70-IN-4

HSP70-IN-4 (Compound YM-01) 是 Hsp70 抑制剂，其 IC50 为3.2 μM。HSP70-IN-4 不具有血脑屏障渗透性。

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HSP70-IN-4 Chemical Structure

HSP70-IN-4 Chemical Structure

CAS No. : 1427450-47-2

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HSP70-IN-4 的其他形式现货产品:

Customer Review

Other Forms of HSP70-IN-4:

HSP70-IN-4 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HSP70-IN-4 (Compound YM-01) is an Hsp70 inhibitor with an IC50 of 3.2 μM. HSP70-IN-4 is not BBB permeable[1].

IC50 & Target[1]

HSP70

3.2 μM (IC50)

体外研究
(In Vitro)

HSP70-IN-4 (Compound YM-01; 50 μM) 显著增强 Hsp70 与错误折叠蛋白的结合[1]。
HSP70-IN-4 (0-30 μM; 72 h) 抑制 MDA-MB-231、MCF10A 和 MCF7 的活性，EC50 分别为 2.0 ± 0.2、3.3 ± 0.3 和 5.2 ± 0.8 μM[1]。
HSP70-IN-4 在水中稳定 (室温下至少 8 小时)[1]。
HSP70-IN-4 在人肝微粒体中被快速代谢 (t1/2 值为 ~2-4 min)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HSP70-IN-4 相关抗体:

Cell Viability Assay[1]

Cell Line: MCF7, MCF10A and MDA-MB-231
Concentration: 0-30 μM
Incubation Time: 72 h
Result: Inhibited viability with EC50s of 2.0 ± 0.2, 3.3 ± 0.3 and 5.2 ± 0.8 μM for MDA-MB-231, MCF10A and MCF7, respectively.
体内研究
(In Vivo)

HSP70-IN-4 (Compound YM-01) 不能通过血脑屏障[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD1 mice[1]
Dosage: 20 mg/kg
Administration: Intravenous injection (Pharmacokinetic Analysis)
Result: Initial pharmacokinetics of HSP70-IN-4 (Compound YM-01; 20 mg/kg; i.v.)[1]
hour plasma (ng/mL) brain (ng/g) kidney (ng/g)
0.16 359 0 74378
1 324 0 63231
分子量

553.72

Formula

C27H27N3O4S3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HSP70-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSP70-IN-41427450-47-2HSPHeat shock proteinsblood-brain barrierBBBMDA-MB-231MCF10AMCF7Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-18406
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