2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP Apoptosis
  4. Hsp90-Cdc37-IN-2

Hsp90-Cdc37-IN-2 (Compound 41) 是热休克蛋白 90 (Hsp90) 和细胞周期蛋白 37 (Cdc37) 相互作用的抑制剂。Hsp90-Cdc37-IN-2 抑制癌细胞 A549、MCF-7、HOS 和 HepG2 的增殖，IC50 为 0.41-0.94 μM。Hsp90-Cdc37-IN-2 降低线粒体膜电位，诱导 A549 细胞凋亡 (apoptosis)，并在 G0/G1 期阻滞细胞周期。

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Hsp90-Cdc37-IN-2 Chemical Structure

Hsp90-Cdc37-IN-2 Chemical Structure

CAS No. : 2413849-81-5

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Hsp90-Cdc37-IN-2 相关抗体

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查看 HSP 亚型特异性产品:

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hsp90-Cdc37-IN-2 (Compound 41) is an inhibitor for the interaction between heat shock protein 90 (Hsp90) and cyclin 37 (Cdc37). Hsp90-Cdc37-IN-2 inhibits the proliferation of cancer cell A549, MCF-7, HOS and HepG2 with IC50 of 0.41-0.94 μM. Hsp90-Cdc37-IN-2 decreases the mitochondrial membrane potential, induces apoptosis, and arrest cell cycle at G0/G1 phase in A549[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.41 μM
Compound: 41
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 31725288]
HepG2 IC50
0.94 μM
Compound: 41
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 31725288]
HOS IC50
0.9 μM
Compound: 41
Antiproliferative activity against human HOS cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HOS cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 31725288]
MCF7 IC50
0.64 μM
Compound: 41
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 31725288]
分子量

681.83

Formula

C42H48FNO6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hsp90-Cdc37-IN-2 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Hsp90-Cdc37-IN-22413849-81-5HSPApoptosisHeat shock proteinsA549MCF-7HOSHepG2antitumorInhibitorinhibitorinhibit

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