2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. HX600

HX600 是 RXR (Retinoid X Receptor) 异源二聚体复合物的合成激动剂。HX600 可预防缺血引起的神经元损伤。 HX600 具有口服生物活性。

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HX600 Chemical Structure

HX600 Chemical Structure

CAS No. : 172705-89-4

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规格 价格 是否有货 数量
1 mg ￥1800
In-stock
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Customer Review

HX600 相关抗体

Top Publications Citing Use of Products

查看 RAR/RXR 亚型特异性产品:

查看所有亚型
RXRα RXRβ RXRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HX600 is a synthetic agonist for RXR (Retinoid X Receptor) heterodimer complex. HX600 prevents ischemia-induced neuronal damage. HX600 has orally bioactivity[1].

IC50 & Target

RXR α

1.9 μM (Ki)

RXR β

0.64 μM (Ki)

RXR γ

1 μM (Ki)

体外研究
(In Vitro)

HX600 (100-1000 μM, 24 h) 对谷氨酸暴露无直接神经保护作用[1]。
HX600 (1 μM, 24 h) 抑制原代小胶质细胞中炎症介质的表达，防止炎症诱导的神经元死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HX600 相关抗体:

Apoptosis Analysis[1]

Cell Line: Primary Cortical Neuron Cells
Concentration: 0 μM, 0.1 μM, 0.2 μM, 0.5 μM, 1 μM, 2 μM, 5 μM, 10 μM, 20 μM
Incubation Time: 24 h
Result: Showd HX600 was not able to prevent the glutamate induced neuronal death.
体内研究
(In Vivo)

HX600 (60 mg/kg，口服，每 24h) 可减轻永久性缺血模型的缺血损伤和运动缺陷，并可改善缺血脑 Iba-1、phospho-p38 和 TREM-2 的免疫反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ischemic Mice[1]
Dosage: 60 mg/kg
Administration: Oral Gavage (p.o.)
Result: Revealed that mice treated with HX600 had smaller lesion with the size of 21%, and significantly reduction in Iba-1, phospho-p38 and TREM-2 at protein level.
分子量

438.56

Formula

C29H30N2O2
CAS 号
性状

固体

颜色

Yellow to orange

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

COA (183 KB)

产品使用指南 (1538 KB)
参考文献

HX600 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HX600172705-89-4HX 600HX-600RAR/RXRRetinoic acid receptorsRetinoid X receptorsInhibitorinhibitorinhibit

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产品名称：
HX600
目录号：
HY-120875
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