2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. ICI 162846

ICI 162846 是 H2 受体 (receptor) 的口服活性拮抗剂。ICI 162846 在慢性十二指肠溃疡(chronic duodenal ulcer, CDU) 模型中抑制酸的产生并伴随组胺分泌的增加。ICI 162846 能有效预防慢性十二指肠溃疡。

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ICI 162846 Chemical Structure

ICI 162846 Chemical Structure

CAS No. : 84545-30-2

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ICI 162846 相关抗体

Top Publications Citing Use of Products

查看 Histamine Receptor 亚型特异性产品:

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ICI 162846 is an orally active antagonist of H2 receptor. ICI 162846 inhibits acid production accompanied by an increase in the secretion of histamine in chronic duodenal ulcer (CDU) models. ICI 162846 is effective in preventing CDU[1][2].

IC50 & Target[1]

H2 Receptor

 

体内研究
(In Vivo)

ICI 162846 (10 mg/kg，口服，每天两次持续 5 天) 降低了 CFLP 小鼠诱导的 CDU 模型中 CDU 的发生率，并抑制胃酸产生同时伴随组胺分泌增加[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CFLP mice were irradiated to the lower mediastinum to induce CDU[2].
Dosage: 10 mg/kg, twice daily for 5 days
Administration: Oral gavage (p.o.)
Result: Reduced the incidence of CDU.
Inhibited gastric acid secretion about 50% or more in the basal and the stimulated periods.
Induced massive rises in basal (12-fold) and stimulated (9-fold) luminal histamine.
分子量

306.29

Formula

C11H17F3N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ICI 162846 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICI 16284684545-30-2ICI162846ICI-162846Histamine Receptororally activeCDUInhibitorinhibitorinhibit

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产品名称：
ICI 162846
目录号：
HY-101234
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