1. Metabolic Enzyme/Protease Apoptosis
  2. Indoleamine 2,3-Dioxygenase (IDO) Apoptosis Bcl-2 Family
  3. IDO1/TDO-IN-1

IDO1/TDO-IN-1 (30) 是 IDO1 (非竞争性, Ki 为 0.23 μM) and TDO (竞争性, Ki 为 0.73 μM) 的双抑制剂。IDO1/TDO-IN-1 (30) 通过潜在的线粒体介导的Bcl-2/Bax通路显著促进细胞凋亡。

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IDO1/TDO-IN-1 Chemical Structure

IDO1/TDO-IN-1 Chemical Structure

CAS No. : 2379527-72-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IDO1/TDO-IN-1 (30) is a potent dual IDO1 (uncompetitive, Ki of 0.23 μM) and TDO (competitive, Ki of 0.73 μM) inhibitor. IDO1/TDO-IN-1 (30) significantly promotes cell apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway[1].

IC50 & Target[1]

IDO1

0.23 μM (Ki)

TDO

0.73 μM (Ki)

分子量

364.35

Formula

C21H16O6

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
IDO1/TDO-IN-1
目录号:
HY-144778
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