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  4. IgdE protease

IgdE protease 是一种半胱氨酸蛋白酶，最初从 Streptococcus agalactiae 中分离出来。IgdE protease 特异性地消化 IgG1 型单克隆抗体 (mAb) 的上铰链区，产生 Fc/2、铰链肽二聚体和 Fab 片段。IgdE protease 可用于二硫键和游离硫醇分析，因为它可以在没有还原剂的条件下进行切割。

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IgdE protease Chemical Structure

IgdE protease Chemical Structure

CAS No. : 1892548-76-3

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生物活性

IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage[1].

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  • Do most proteins show cross-species activity?

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Keywords:

IgdE protease1892548-76-3Biochemical Assay ReagentsIdeSmonoclonal antibodydisulfide bondssulfhydrylsInhibitorinhibitorinhibit

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