2. Apoptosis Immunology/Inflammation Membrane Transporter/Ion Channel
  3. TNF Receptor Interleukin Related Potassium Channel
  4. Immuno modulator-1

Immuno modulator-1 (compound 22) 抑制人外周血单核细胞 (hPBMC) 中 TNFα 和 IL-2 的分泌，IC50 值分别为 4.7 和 26 nM 。Immuno modulator-1 具有 hERG 钾通道阻断作用，3 μM时抑制率为20%。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

Immuno modulator-1 Chemical Structure

Immuno modulator-1 Chemical Structure

CAS No. : 2757469-20-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Immuno modulator-1 相关抗体

Top Publications Citing Use of Products

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows hERG potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM[1].

IC50 & Target

IL-2

 

体外研究
(In Vitro)

Immuno modulator-1 (compound 22) 抑制 NCI-H929 人骨髓瘤细胞的增殖，IC50 为 0.6 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Immuno modulator-1 相关抗体:
体内研究
(In Vivo)

Immuno modulator-1 (compound 22) (1 mg/kg (IV), 5 mg/kg (PO); once) 在雄性 Sprague-Dawley 大鼠中的口服生物利用度为30%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 1 mg/kg (IV), 5 mg/kg (PO)
Administration: IV (2 mL/kg), PO (10 mL/kg); once (Pharmacokinetic Analysis)
Result: Pharmacokinetic Parameters of Immuno modulator-1 in male Sprague-Dawley rats[1].
IV (1 mg/kg) PO (5 mg/kg)
Cmax (ng/mL) 1437
AUC0-24 (ng/mL∗h) 13029
CL (mL/min/kg) 2.2
Vss (L/kg) 0.36
F (%) 30%
分子量

582.62

Formula

C32H31FN6O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Immuno modulator-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Immuno modulator-12757469-20-6Immuno modulator1Immuno modulator 1TNF ReceptorInterleukin RelatedPotassium ChannelTumor Necrosis Factor ReceptorTNFRILKcsAhPBMCNCI-H929myeloma cellperipheral blood mononuclear cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Immuno modulator-1
目录号：
HY-153952
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z