2. Antibody-drug Conjugate/ADC Related GPCR/G Protein Apoptosis
  3. Antibody-Drug Conjugates (ADCs) Guanylate Cyclase Apoptosis
  4. Indusatumab vedotin

Indusatumab vedotin  (Synonyms: MLN0264; TAK-264)

目录号: HY-P99662
技术支持

Indusatumab vedotin (MLN-0264; AKT-264) 是一种抗体-药物偶联物 (ADC)，由人抗鸟苷酸环化酶 C (guanylate cyclase, GCC) 与微管破坏剂单 Monomethyl auristatin (HY-15162) 连接而组成。Indusatumab vedotin 对胰腺癌细胞系具有抗增殖作用。Indusatumab vedotin 使细胞周期停滞在 G2/M 期，并诱导细胞凋亡 (apoptosis)。

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Indusatumab vedotin Chemical Structure

Indusatumab vedotin Chemical Structure

CAS No. : 1514889-12-3

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Indusatumab vedotin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Indusatumab vedotin (MLN-0264; AKT-264) is an antibody-drug conjugate (ADC) consisting of the human anti-guanylate cyclase C (GCC) antibody linked to a microtubule-disruptor Monomethyl auristatin (HY-15162). Indusatumab vedotin has anti-proliferative effects on pancreas cancer cell lines. Indusatumab vedotin arrests cell cycle at G2/M phase, and induces apoptosis[1].

IC50 & Target

Guanylate cyclase (GCC)[1]
体外研究
(In Vitro)

Indusatumab vedotin (0.4-25 μg/mL；72 小时) 在胰腺癌细胞系中引起抗增殖作用[1]。
Indusatumab vedotin (12.5 μg/mL；24 小时) 使 MIA PaCa-2 和 PANC-1 细胞的细胞周期停滞在 G2/M 期，并引起 P-Hitone H3 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Indusatumab vedotin 相关抗体:

Western Blot Analysis[1]

Cell Line: MIA PaCa-2 and PANC-1 cells
Concentration: 12.5 μg/mL
Incubation Time: 24 hours
Result: Increased the protein level of P-Hitone H3, indicating tubulin polymerization.

Cell Cycle Analysis[1]

Cell Line: MIA PaCa-2 and PANC-1 cells
Concentration: 12.5 μg/mL
Incubation Time: 24 hours
Result: Decreased cell number in G1 phase and caused an induction of a G2/M arrest.

Western Blot Analysis[1]

Cell Line: GCC Knock cells and Pancreatic cancer cell lines: L3.6, MIA PaCa-2, Panc 03.27, Panc 05.04 and Panc 02.03
Concentration: 0.4 μg/mL, 0.8 μg/mL, 1.6 μg/mL, 3.1 μg/mL, 6.3 μg/mL, 12.5 μg/mL, and 25 μg/mL
Incubation Time: 72 hours
Result: Inhibited the cell viability of pancreatic cancer cells, but not GCC Knock cells.
体内研究
(In Vivo)

Indusatumab vedotin (10 mg/kg；静脉注射；每周一次，至少持续 17 天) 显着降低肿瘤的生长速度[1]。
Indusatumab vedotin 在携带六种不同异种移植模型之一的小鼠中显示出与暴露密切相关的生物活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pancreas Explant Xenograft Model in Mouse[1]
Dosage: 10 mg/kg
Administration: Intravenous injection in tail; once weekly for 17-50 days
Result: Inhibited the volume growth of 10 types tumors significantly.
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Indusatumab vedotin 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Indusatumab vedotin1514889-12-3MLN0264 TAK-264MLN 0264MLN-0264TAK264TAK 264TAK-264Antibody-Drug Conjugates (ADCs)Guanylate CyclaseApoptosisAntibody-Drug ConjugatesInhibitorinhibitorinhibit

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