2. Anti-infection
  3. Influenza Virus
  4. Influenza virus-IN-3

Influenza virus-IN-3 (compound 9) 是一种有效的选择性流感病毒抑制剂，H5N1、H5N2、H5N6、H5N8 的 IC50s 分别为 0.88、0.10、5.5、0.51 µM。Influenza virus-IN-3 显示出抗病毒和 NA (神经氨酸酶) 抑制活性。Influenza virus-IN-3 具有低细胞毒性，CC50 >200 µM。

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Influenza virus-IN-3 Chemical Structure

Influenza virus-IN-3 Chemical Structure

CAS No. : 2412451-16-0

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Influenza virus-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Influenza virus-IN-3 (compound 9) is a potent and selective influenza virus inhibitor with IC50s of 0.88, 0.10, 5.5, 0.51 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-3 shows antiviral and NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-3 shows low cytotoxicity with an CC50 of >200 µM[1].

IC50 & Target

IC50: 0.88 µM (H5N1); 0.10 µM (H5N2); 5.5 µM (H5N6); 0.51 µM (H5N8)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Fibroblast CC50
> 200 μM
Compound: 9a
Cytotoxicity against chicken embryo fibroblast assessed as reduction in cell viability after 48 hrs by CCK8 assay
Cytotoxicity against chicken embryo fibroblast assessed as reduction in cell viability after 48 hrs by CCK8 assay
[PMID: 32092589]
体外研究
(In Vitro)

Influenza virus-IN-3 (compound 9a) shows NA (neuraminidase enzyme)-inhibitory activity with IC50s of 118.17, 1442.6, 34543.33, 78.06, 10206, 0.00048, 0.01222 nM for H5N1, H5N2, H5N6, H5N8, H5N1eH274Y, N1 (H1N1pdm09) and N2 (H3N2), respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Influenza virus-IN-3 相关抗体:
分子量

456.60

Formula

C25H32N2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Influenza virus-IN-3 相关分类

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  • 稀释计算器

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Influenza virus-IN-32412451-16-0Influenza Virusoseltamivir derivativeslow cytotoxicityneuraminidase enzymeantiviralchicken embryo fibroblast cellsInhibitorinhibitorinhibit

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