Insulin glargine  (Synonyms: 甘精胰岛素)

Insulin glargine is a long-acting insulin analog. Insulin glargine has the effect of lowering blood sugar and can be used in the research of diabetes. In addition, high doses of Insulin glargine can promote the proliferation of bladder cancer cells^[1][2][3][4].

Insulin glargine (10-100 IU/L; 0-72 小时) 以 PI3K 非依赖性的方式激活 Akt，进而促进膀胱癌细胞增殖^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Insulin glargine (2-12.5 IU/kg; 皮下注射; 3-12 个月) 在啮齿动物中，未呈现出致癌风险^[2]。
Insulin glargine (450 mg/kg; 皮下注射; 6 个月) 在糖尿病小鼠模型中具有改善作用^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

6062.89

C₂₆₇H₄₀₄N₇₂O₇₈S₆

160337-95-1

液体

Colorless to light yellow

A-chain: Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Gly; B-chain: Phe-Val-Asn-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Thr-Arg-Arg (Disulfide bridge: CysA6-CysA11, CysA7-CysB7, CysA20-CysB19)

A-chain: GIVEQCCTSICSLYQLENYCG; B-chain: FVNQHLCGSHLVEALYLVCGERGFFYTPKTRR (Disulfide bridge: CysA6-CysA11, CysA7-CysB7, CysA20-CysB19)

Room temperature in continental US; may vary elsewhere.

Store at 4°C, do not freeze

• [1]. Liu S, et al. High dose human insulin and insulin glargine promote T24 bladder cancer cell proliferation via PI3K-independent activation of Akt. Diabetes Res Clin Pract. 2011 Feb;91(2):177-82.  [Content Brief]

  [2]. Stammberger I, et al. Evaluation of the carcinogenic potential of insulin glargine (LANTUS) in rats and mice. Int J Toxicol. 2002 May-Jun;21(3):171-9.  [Content Brief]

  [3]. Li Y, et al. Comparative Study of Liraglutide and Insulin Glargine on Glycemic Control and Pancreatic β-Cell Function in db/db Mice. Med Sci Monit. 2018 May 19;24:3293-3300.  [Content Brief]

  [4]. Hwang HG, et al. Recombinant Glargine Insulin Production Process Using Escherichia coli. J Microbiol Biotechnol. 2016;26(10):1781-1789.  [Content Brief]