2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. IOX2 sodium

IOX2 sodium 是一种特异性的脯氨酰羟化酶-2 (PHD2) 抑制剂，IC50 为 22 nM。IOX2 sodium 能够上调 HIF-1α 的表达并抑制 ROS 的产生来调节血小板功能和动脉血栓形成。IOX2 sodium 可用于血栓性疾病的研究。

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IOX2 sodium Chemical Structure

IOX2 sodium Chemical Structure

CAS No. : 2377239-85-3

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IOX2 sodium 的其他形式现货产品:

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Other Forms of IOX2 sodium:

IOX2 sodium 相关抗体

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查看 HIF/HIF Prolyl-Hydroxylase 亚型特异性产品:

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HIF-1α HIF

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IOX2 sodium is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM. IOX2 sodium regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 sodium can be used in the study of thrombotic diseases[1][2].

IC50 & Target

IC50: 22 nM (PHD2)[2]
体外研究
(In Vitro)

IOX2 sodium (0、10、25 和 50 μM) 剂量依赖性地抑制胶原蛋白相关肽 (CRP；0.25μg/mL) 或凝血酶 (0.03 U/mL) 诱导的血小板聚集和 ATP 释放。 但 IOX2 不影响 P-选择素表达和糖蛋白 (GP)Ibα、GPVI 或 αIIbβ3 的表面水平[1]。
IOX2 sodium 还抑制血小板在纤维蛋白原或胶原蛋白上的扩散和凝块回缩[1]。
IOX2 sodium (50 μM；24 h) 增加正常人的表皮角质形成细胞 (NHEK) 和正常人真皮成纤维细胞 (NHDF) 在常氧和缺氧条件下生长时 VEGF-A 和 BNIP3 的转录水平[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IOX2 sodium 相关抗体:
体内研究
(In Vivo)

IOX2 sodium (10 mg/kg；腹腔注射；单剂量) 损害小鼠体内血小板的止血功能和动脉血栓形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection
Result: Upregulated HIF-1α in platelets, decreased ROS generation, and downregulated NOX1 expression.
Increased the phosphorylation level of VASP (Ser157/239), and inhibited the phosphorylation of p38 (Thr180/Tyr182), ERK1/2 (Thr202/Tyr204), AKT (Thr308/Ser473), and PKCδ (Thr505) in CRP- or thrombin-stimulated platelets.
分子量

374.32

Formula

C19H15N2NaO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IOX2 sodium 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IOX22377239-85-3IOX 2IOX-2HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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