2. Stem Cell/Wnt
  3. Wnt
  4. Ipafricept

Ipafricept  (Synonyms: OMP-54F28; FZD8-Fc)

目录号: HY-P99667 纯度: 99.80%
COA 技术支持

Ipafricept (OMP-54F28; FZD8-Fc) 是第一类重组融合蛋白 (recombinant fusion protein)，由人卷曲-8 受体的细胞外部分与人 IgG1 Fc 片段融合，该片段结合 Wnt 配体，阻断 Wnt 信号传导。Ipafricept 在胰腺癌小鼠模型中与 Gemcitabine (HY-17026) 联合使用可降低肿瘤生长，减少肝脏和肺转移。Ipafricept 表现出良好耐受性的实体肿瘤抑制作用，比如硬纤维瘤、生殖细胞癌、卵巢癌。

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CAS No. : 1391727-24-4

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1 mg ￥6200
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Ipafricept 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ipafricept (OMP-54F28; FZD8-Fc) is a first class recombinant fusion protein with the extracellular part of the human frizzled-8 receptor fused to a human IgG1 Fc fragment that binds Wnt ligands, which blocks Wnt signaling. Ipafricept reduces tumor growth and results in a decrease in both liver and lung metastases combined with Gemcitabine (HY-17026) in pancreatic cancer mouse models. Ipafricept shows solid tumor inhibition activity with well tolerance, such as desmoid tumor, germ cell cancer, ovarian cancer[1][2][3].

种属

Human
IC50 & Target

Wnt ligand[1]
体外研究
(In Vitro)

Ipafricept (10 μg/mL, 4 小时) 抑制肽 RL-QN15 对人胚胎干细胞 (hESCs) 的促增殖和迁移作用[3]。
Ipafricept (10 μg/mL, 0-48 小时) 可逆转 RL-QN15 诱导的 Wnt/β-catenin 信号通路的激活，从而逆转 RL-QN15 对 hESCs 增殖、迁移和干细胞性的影响[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ipafricept 相关抗体:

Western Blot Analysis[3]

Cell Line: Human embryonic stem cells
Concentration: 10 μg/mL
Incubation Time: 4 h
Result: Markedly reduced the RL-QN15-induced increase in TCF7L1, TCF7L2 levels and stemness of hESCs, as well as CK19 protein levels in hESCs.
体内研究
(In Vivo)

Ipafricept (每周 10 mg/kg 或每 2 周 25 mg/kg, 腹腔注射, 总共 42 天) 与 Gemcitabine (HY-17026) (每周 50 mg/kg 或 5 mg/kg) 和 Nab-paclitaxel (HY-P99974) (每周 10 mg/kg) 联合使用在胰腺癌异种移植的小鼠模型中可促进肿瘤生长抑制[2]。
Ipafricept (45 mg/kg/2 周, 腹腔注射, 总共 42 天) 在卵巢癌异种移植的小鼠模型中与 Nab-paclitaxel (HY-P99974) (7.5 mg/kg/周) 联合使用比 Carboplatin (HY-17393) (30 mg/kg/周) 的抗肿瘤活性更强[2]。
Ipafricept (10 mg/kg, 皮下注射，第 0 天和第 3 天给药) 在小鼠全层皮肤损伤模型中与 RL-QN15 竞争结合，减少 RL-QN15 与 FZD8 的相互作用，从而抵消其对 Wnt/β-catenin 信号通路的激活[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pancreatic cancer xenograft mouse models[2]
Dosage: 10 mg/kg weekly or 25 mg/kg every 2 weeks
Administration: i.p., weekly or every 2 weeks for 42 days
Result: Markedly increased the antitumor activity in combination with Gemcitabine (HY-17026) and Nab-paclitaxel (HY-P99974) in pancreatic cancer xenograft mouse models.
Animal Model: Ovarian cancer xenograft mouse models[2]
Dosage: 45 mg/kg every 2 weeks
Administration: i.p., every 2 weeks for 42 days
Result: Resulted in greater tumor growth inhibition in combination with Nab-paclitaxel (HY-P99974) than Carboplatin (HY-17393) in ovarian cancer xenograft mouse models.
Animal Model: Mouse full-thickness skin injury models[3]
Dosage: 10 mg/kg
Administration: s.c., administered on day 0 and 3
Result: Decreased the skin wound healing rate to less than 60% combined with RL-QN15 and inhibited RL-QN15-induced re-epithelialization in mouse full-thickness skin injury models.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • [FZD8 (frizzled class receptor 8, frizzled family receptor 8, Frizzled-8)]2-IGHG1 Fc (Fragment constant)
纯度 & 产品资料

纯度: 99.80%

COA (264 KB) SDS-PAGE (78 KB) SEC-HPLC (168 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Ipafricept 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ipafricept1391727-24-4OMP-54F28 FZD8-FcWntfusion proteinWnt signalingliver and lung metastasestumor growthdesmoid tumorgerm cell cancerovarian cancerInhibitorinhibitorinhibit

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