2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. IQTub4P

IQTub4P 是一种有效的微管 (microtubule ) 抑制剂。IQTub4P 在 HeLa 细胞中具有细胞毒性，其 EC50 为 170 nM。IQTub4P 抑制微管结构和功能。IQTub4P 在体内时耐受良好。

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IQTub4P Chemical Structure

IQTub4P Chemical Structure

CAS No. : 2376321-67-2

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IQTub4P 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IQTub4P is a potent microtubule (MT) inhibitor. IQTub4P has the cytotoxicity in in HeLa cells, with EC50 of 170 nM. IQTub4P inhibits microtubule structure and function. IQTub4P is well-tolerated in vivo[1].

体外研究
(In Vitro)

IQTub4P (48 h) shows strong dose-dependent cytotoxicity in HeLa cells[1].
IQTub4P (0-750 nM, 15 min) shows dose-dependent microtubule network depolymerisation, leads to mitotic arrests and the formation of aberrant multipolar spindles with resulting unstructured chromosome alignment at 120 nM[1].
IQTub4P (0-1.25 μM, 24 h) shows potent induction of G2/M arrest[1].
IQTub4P (10 μM, 2 min) shows potent inhibition of cellular tubulin polymerisation dynamics[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IQTub4P 相关抗体:

Cell Viability Assay

Cell Line: HeLa cells[1]
Concentration:
Incubation Time: 48 h
Result: Showed strong dose-dependent cytotoxicity in HeLa cells, with EC50 of 170 nM, and displayed near-identical cytotoxicity in cell culture as its free phenol form IQTub4 (EC50 = 120 nM).

Cell Cycle Analysis

Cell Line: HeLa cells[1]
Concentration: 0, 0.06, 0.12, 0.5, 0.75, 1.25 μM
Incubation Time: 24 h
Result: Showed potent induction of G2/M arrest, and showed extensive G2/M-arrest from 500 nM.
体内研究
(In Vivo)

IQTub4P (Balb/c mice, 25 mg/kg, IP and IV, once every two days, 3 administrations) is well-tolerated in vivo and can avoid short-term cumulative toxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice (female)[1]
Dosage: 25 mg/kg
Administration: IP and IV, 3 administration, 48 h intervals
Result: Could avoid short-term cumulative toxicity, and was well-tolerated in vivo, with a single-administration maximal tolerated dose of 32 mg/kg (i.p.) and 50 mg/kg (i.v.).
分子量

465.30

Formula

C19H18NNa2O8P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IQTub4P 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IQTub4P2376321-67-2Microtubule/TubulinWell-toleratedMicrotubule dynamicsTubulin polymerisationInhibitorinhibitorinhibit

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目录号：
HY-146692
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