2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. IQTub4P

IQTub4P 是一种有效的微管 (microtubule ) 抑制剂。IQTub4P 在 HeLa 细胞中具有细胞毒性，其 EC50 为 170 nM。IQTub4P 抑制微管结构和功能。IQTub4P 在体内时耐受良好。

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IQTub4P Chemical Structure

IQTub4P Chemical Structure

CAS No. : 2376321-67-2

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IQTub4P 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IQTub4P is a potent microtubule (MT) inhibitor. IQTub4P has the cytotoxicity in in HeLa cells, with EC50 of 170 nM. IQTub4P inhibits microtubule structure and function. IQTub4P is well-tolerated in vivo[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa EC50
170 nM
Compound: IQTub4P
Antiproliferative activity against human HeLa cells assessed as reduction in cell growth after 48 hrs by resazurin dye based fluorescence assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell growth after 48 hrs by resazurin dye based fluorescence assay
[PMID: 31735573]
HL-60 EC50
570 nM
Compound: IQTub4P
Antiproliferative activity against human HL-60 cells assessed as reduction in cell growth after 24 hrs by MTT assay
Antiproliferative activity against human HL-60 cells assessed as reduction in cell growth after 24 hrs by MTT assay
[PMID: 31735573]
体外研究
(In Vitro)

IQTub4P (48 h) shows strong dose-dependent cytotoxicity in HeLa cells[1].
IQTub4P (0-750 nM, 15 min) shows dose-dependent microtubule network depolymerisation, leads to mitotic arrests and the formation of aberrant multipolar spindles with resulting unstructured chromosome alignment at 120 nM[1].
IQTub4P (0-1.25 μM, 24 h) shows potent induction of G2/M arrest[1].
IQTub4P (10 μM, 2 min) shows potent inhibition of cellular tubulin polymerisation dynamics[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IQTub4P 相关抗体:

Cell Viability Assay

Cell Line: HeLa cells[1]
Concentration:
Incubation Time: 48 h
Result: Showed strong dose-dependent cytotoxicity in HeLa cells, with EC50 of 170 nM, and displayed near-identical cytotoxicity in cell culture as its free phenol form IQTub4 (EC50 = 120 nM).

Cell Cycle Analysis

Cell Line: HeLa cells[1]
Concentration: 0, 0.06, 0.12, 0.5, 0.75, 1.25 μM
Incubation Time: 24 h
Result: Showed potent induction of G2/M arrest, and showed extensive G2/M-arrest from 500 nM.
体内研究
(In Vivo)

IQTub4P (Balb/c mice, 25 mg/kg, IP and IV, once every two days, 3 administrations) is well-tolerated in vivo and can avoid short-term cumulative toxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice (female)[1]
Dosage: 25 mg/kg
Administration: IP and IV, 3 administration, 48 h intervals
Result: Could avoid short-term cumulative toxicity, and was well-tolerated in vivo, with a single-administration maximal tolerated dose of 32 mg/kg (i.p.) and 50 mg/kg (i.v.).
分子量

465.30

Formula

C19H18NNa2O8P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IQTub4P 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IQTub4P2376321-67-2Microtubule/TubulinWell-toleratedMicrotubule dynamicsTubulin polymerisationInhibitorinhibitorinhibit

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