2. Immunology/Inflammation
  3. IRAK
  4. IRAK4-IN-18

IRAK4-IN-18 是一种有效的白介素 1 受体相关激酶 4 (IRAK4) 抑制剂，IC50 为 15 nM。IRAK4-IN-18 可抑制 THP 和 DC 细胞中 LPS 诱导的 IL23 产生，阻止关节炎模型大鼠的关节炎发展。IRAK4-IN-18 可用于关节炎疾病的研究。

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IRAK4-IN-18 Chemical Structure

IRAK4-IN-18 Chemical Structure

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IRAK4-IN-18 相关抗体

Top Publications Citing Use of Products

查看 IRAK 亚型特异性产品:

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IRAK1 IRAK4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IRAK4-IN-18 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 value of 15 nM. IRAK4-IN-18 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-18 can be used for researching arthritis disease[1].

IC50 & Target[1]

IRAK4

15 nM (IC50)

体外研究
(In Vitro)

IRAK4-IN-18 (compound 33) has inhibitory activity against LPS-induced IL23 in THP and DC with IC50s of 0.25 and 0.14 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IRAK4-IN-18 相关抗体:
体内研究
(In Vivo)

IRAK4-IN-18 (5, 10 and 20 mg/kg; twice daily for 21 days) exhibits good efficacy in a mouse model for the inhibition of IL-6 production induced by IL-1β, and completely stops arthritis development in arthritis rats at 30 mg/kg[1].
IRAK4-IN-18 (1 mg/kg for IV, 5 mg/kg for PO, single dosage) exhibits a favorable pharmacokinetics profile with a clearance of 53 mL/min/kg and oral bioavailability of 38%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Collagen-induced arthritis (CIA) rat models[1]
Dosage: 5, 10 and 20 mg/kg
Administration: twice daily for 21 days
Result: Completely stopped arthritis development based on hind paw clinical scores at 30 mg/kg dose, twice daily, and effectively decreased disease progression with 97% inhibition at 20 mg/kg dose, 56% inhibition at 10 mg/kg dose and 30% inhibition at 5 mg/kg dose.
分子量

464.49

Formula

C24H25FN6O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IRAK4-IN-18 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IRAK4-IN-18IRAKInterleukin-1 receptor associated kinaseIL-1R associated kinaseArthritisLPSIL23,THPDCcollagenanti-inflammatoryInhibitorinhibitorinhibit

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产品名称：
IRAK4-IN-18
目录号：
HY-150732
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