Isatuximab  (Synonyms: 艾萨妥昔单抗)

Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions^[1][2].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Chimeric

一项体外研究表明，与单独使用 Isatuximab 相比，Isatuximab 与 Pomalidomide 的组合导致更大的直接毒性和效应细胞对 CD38+ 多发性骨髓瘤细胞的裂解^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1461640-62-9

液体

Colorless to light yellow

艾萨妥昔单抗

Please store the product under the recommended conditions in the Certificate of Analysis.

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  Human IgG1 kappa

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  Immobilized CD38 Protein, Human can bind Isatuximab. The EC₅₀ for this effect is 6.163 ng/mL.

• [1]. Dhillon S. Isatuximab: First Approval [published correction appears in Drugs. 2020 May 23;:]. Drugs. 2020;80(9):905-912.  [Content Brief]

  [2]. Attal M, et al. Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): a randomised, multicentre, open-label, phase 3 study [published correction appears in Lancet. 2019 Dec 7;394(10214):2072]. Lancet. 2019;394(10214):2096-2107.  [Content Brief]