2. Apoptosis Autophagy
  3. Apoptosis Autophagy
  4. Isoangustone A

Isoangustone A 是一种抗癌和抗炎剂。Isoangustone A 诱导癌细胞凋亡 (apoptosis) 和自噬 (autophagic)。

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Isoangustone A Chemical Structure

Isoangustone A Chemical Structure

CAS No. : 129280-34-8

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Isoangustone A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Isoangustone A is an anticancer and anti-inflammatory agent. Isoangustone A induces cancer cells apoptosis and autophagic cell death[1][2][3].

IC50 & Target

Apoptosis, Autophagy[2]
体外研究
(In Vitro)

Isoangustone A (10 and 20 μM; 48 and 72 h) 抑制 SK-MEL-28 细胞增殖并诱导 G1 期细胞周期阻滞[1]。
Isoangustone A (10 and 20 μM; 48 h) 通过 Akt/GSK3β 和 MKK4/MKK7/JNKs 信号通路介导 G1 期相关蛋白的丰度降低[1]。
Isoangustone A 通过 ATP 竞争方式直接结合抑制 PI3-K、MKK4 和 MKK7 激酶活性[1]。
Isoangustone A (20 μM; 0.5-4 h) 通过激活 AMPK 信号诱导结直肠癌细胞自噬[2]。
Isoangustone A (1-20 μM; 0-100 min) 抑制线粒体呼吸[2]。
Isoangustone A (15 μM; 6 h) 诱导 SW480 细胞凋亡[2]。
Isoangustone A (1-20 μΜ; 3 days) 抑制人肾系膜细胞的纤维化和炎症[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Isoangustone A 相关抗体:

Cell Proliferation Assay[1]

Cell Line: SK-MEL-28
Concentration: 10 and 20 μM
Incubation Time: 48 and 72 h
Result: Inhibited proliferation in a dose- and time-dependent manner.

Cell Cycle Analysis[1]

Cell Line: SK-MEL-28
Concentration: 10 and 20 μM
Incubation Time: 48 h
Result: Caused cell cycle arrest at G1 phase.

Western Blot Analysis[1]

Cell Line: SK-MEL-28
Concentration: 10 and 20 μM
Incubation Time: 48 h
Result: Inhibited the expression of cyclin D1 and cyclin E. Suppressed phosphorylation of Rb in a dose-dependent manner. Inhibited the phosphorylation of Akt (Ser473, Thr308) and GSK3β (Ser9). Suppressed the phosphorylation of JNK1/2, but had no effect on ERK1/2 or p38.

Cell Autophagy Assay[2]

Cell Line: SW480 cells
Concentration: 20 μM
Incubation Time: 0.5, 2 and 4 h
Result: Deformed mitochondria, nondegradable cellular debris were all observable together with autophagic vacuoles in cells after 4 h.

Apoptosis Analysis[2]

Cell Line: SW480 cells
Concentration: 15 μM
Incubation Time: 6 h
Result: Induced elevation of apoptotic Annexin V+/PI- and Annexin V+/PI+ cell populations.
体内研究
(In Vivo)

Isoangustone A (2 or 10 mg/kg; i.p.; daily for 35 days) 显著降低小鼠 SK-MEL-28 异种移植物的肿瘤生长、体积和重量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Balb/c nu/nu mice, SK-MEL-28 xenograft model[1]
Dosage: 2 or 10 mg/kg
Administration: Intraperitoneal injection, daily for 35 days
Result: Significantly suppressed tumor weight compared to the control group. Markedly inhibited the expression of proliferating cell nuclear antigen (PCNA). Decreased phosphorylation levels of Akt.
分子量

422.47

Formula

C25H26O6
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥96.0%

COA (190 KB)

产品使用指南 (1538 KB)
参考文献

Isoangustone A 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isoangustone A129280-34-8ApoptosisAutophagySK-MEL-28PI3-KMKK4MKK7colorectal cancerSW480fibrosisinflammationhuman renal mesangial cellsInhibitorinhibitorinhibit

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