2. Apoptosis Autophagy
  3. Apoptosis Autophagy
  4. Isoangustone A

Isoangustone A 是一种抗癌和抗炎剂。Isoangustone A 诱导癌细胞凋亡 (apoptosis) 和自噬 (autophagic)。

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Isoangustone A Chemical Structure

Isoangustone A Chemical Structure

CAS No. : 129280-34-8

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Isoangustone A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Isoangustone A is an anticancer and anti-inflammatory agent. Isoangustone A induces cancer cells apoptosis and autophagic cell death[1][2][3].

IC50 & Target

Apoptosis, Autophagy[2]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
6.4 μM
Compound: 10
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTS assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTS assay
[PMID: 26841168]
HepG2 IC50
4.4 μM
Compound: 10
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay
[PMID: 26841168]
MCF7 IC50
6.6 μM
Compound: 10
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTS assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTS assay
[PMID: 26841168]
SW480 IC50
6.5 μM
Compound: 10
Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 24 hrs by MTS assay
Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 24 hrs by MTS assay
[PMID: 26841168]
体外研究
(In Vitro)

Isoangustone A (10 and 20 μM; 48 and 72 h) 抑制 SK-MEL-28 细胞增殖并诱导 G1 期细胞周期阻滞[1]。
Isoangustone A (10 and 20 μM; 48 h) 通过 Akt/GSK3β 和 MKK4/MKK7/JNKs 信号通路介导 G1 期相关蛋白的丰度降低[1]。
Isoangustone A 通过 ATP 竞争方式直接结合抑制 PI3-K、MKK4 和 MKK7 激酶活性[1]。
Isoangustone A (20 μM; 0.5-4 h) 通过激活 AMPK 信号诱导结直肠癌细胞自噬[2]。
Isoangustone A (1-20 μM; 0-100 min) 抑制线粒体呼吸[2]。
Isoangustone A (15 μM; 6 h) 诱导 SW480 细胞凋亡[2]。
Isoangustone A (1-20 μΜ; 3 days) 抑制人肾系膜细胞的纤维化和炎症[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Isoangustone A 相关抗体:

Cell Proliferation Assay[1]

Cell Line: SK-MEL-28
Concentration: 10 and 20 μM
Incubation Time: 48 and 72 h
Result: Inhibited proliferation in a dose- and time-dependent manner.

Cell Cycle Analysis[1]

Cell Line: SK-MEL-28
Concentration: 10 and 20 μM
Incubation Time: 48 h
Result: Caused cell cycle arrest at G1 phase.

Western Blot Analysis[1]

Cell Line: SK-MEL-28
Concentration: 10 and 20 μM
Incubation Time: 48 h
Result: Inhibited the expression of cyclin D1 and cyclin E. Suppressed phosphorylation of Rb in a dose-dependent manner. Inhibited the phosphorylation of Akt (Ser473, Thr308) and GSK3β (Ser9). Suppressed the phosphorylation of JNK1/2, but had no effect on ERK1/2 or p38.

Cell Autophagy Assay[2]

Cell Line: SW480 cells
Concentration: 20 μM
Incubation Time: 0.5, 2 and 4 h
Result: Deformed mitochondria, nondegradable cellular debris were all observable together with autophagic vacuoles in cells after 4 h.

Apoptosis Analysis[2]

Cell Line: SW480 cells
Concentration: 15 μM
Incubation Time: 6 h
Result: Induced elevation of apoptotic Annexin V+/PI- and Annexin V+/PI+ cell populations.
体内研究
(In Vivo)

Isoangustone A (2 or 10 mg/kg; i.p.; daily for 35 days) 显著降低小鼠 SK-MEL-28 异种移植物的肿瘤生长、体积和重量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Balb/c nu/nu mice, SK-MEL-28 xenograft model[1]
Dosage: 2 or 10 mg/kg
Administration: Intraperitoneal injection, daily for 35 days
Result: Significantly suppressed tumor weight compared to the control group. Markedly inhibited the expression of proliferating cell nuclear antigen (PCNA). Decreased phosphorylation levels of Akt.
分子量

422.47

Formula

C25H26O6
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥96.0%

COA (190 KB)

产品使用指南 (1538 KB)
参考文献

Isoangustone A 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isoangustone A129280-34-8ApoptosisAutophagySK-MEL-28PI3-KMKK4MKK7colorectal cancerSW480fibrosisinflammationhuman renal mesangial cellsInhibitorinhibitorinhibit

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