2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. Izilendustat hydrochloride

Izilendustat (hydrochloride) 是一种有效的脯氨酰羟化酶 (prolyl hydroxylase) 抑制剂，可稳定缺氧诱导因子-1 α (HIF-1α) 和缺氧诱导因子-2 (HIF-2)。Izilendustat (hydrochloride) 具有研究 HIF-1α 相关疾病的潜力，包括外周血管疾病（PVD）、冠状动脉疾病（CAD）、心力衰竭、缺血、贫血、结肠炎和其他炎症性肠病 (信息提取自专利 WO2011057115A1/WO2011057112A1/WO2011057121A1)。

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Izilendustat hydrochloride Chemical Structure

Izilendustat hydrochloride Chemical Structure

CAS No. : 1303513-80-5

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Izilendustat hydrochloride 的其他形式现货产品:

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Izilendustat hydrochloride 相关抗体

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HIF-1α HIF

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Izilendustat (hydrochloride) is a potent inhibitor of prolyl hydroxylase which stabilizes hypoxia inducible factor- 1 alpha (HIF- lα), as well as hypoxia inducible factor-2 (HIF-2). Izilendustat (hydrochloride) has the potential for the research of HIF- lα related diseases including Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, anemia, colitis, and other inflammatory bowel diseases (extracted from patent WO2011057115A1/WO2011057112A1/WO2011057121A1)[1][2][3].

IC50 & Target

prolyl hydroxylase[1]
分子量

470.39

Formula

C22H29Cl2N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Izilendustat hydrochloride 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Izilendustat1303513-80-5HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHprolyl hydroxylaseHIF-1αHIF-2Peripheral Vascular DiseaseCoronary Artery Diseaseheart failureanemiaischemiacolitisInhibitorinhibitorinhibit

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