2. Epigenetics
  3. Histone Demethylase
  4. JQKD82

JQKD82  (Synonyms: JADA82; PCK82)

目录号: HY-138691
产品使用指南

摩尔计算器

JQKD82 (JADA82) 是一种细胞通透性和选择性 KDM5 抑制剂。JQKD82 增加 H3K4me3，可用于多发性骨髓瘤的研究。

该游离形式化合物不稳定，推荐具有相同生物学活性的稳定盐形式。

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JQKD82 Chemical Structure

JQKD82 Chemical Structure

CAS No. : 2410512-38-6

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     可免费申领三个不同产品的试用装。

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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JQKD82 的其他形式现货产品:

Customer Review

Other Forms of JQKD82:

JQKD82 相关抗体

Top Publications Citing Use of Products

查看 Histone Demethylase 亚型特异性产品:

查看所有亚型
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JQKD82 (JADA82) is a cell-permeable and selective KDM5 inhibitor. JQKD82 increases H3K4me3 and can be used for the research of multiple myeloma[1].

IC50 & Target

KDM5

 

体外研究
(In Vitro)

JQKD82 (0.3 μM; 24 hours) causes an increase in the global H3K4me3 level of MM.1S cells[1].
JQKD82 (0.1-10 μM; day 1-day 5) inhibits the growth of MM.1S cells in a dose- and time-dependent manner. JQKD82 is potent at eliciting growth suppression in MM.1S cells (IC50=0.42 μM)[1].
JQKD82 (1 μM; 24 hours) induces G1 cell-cycle arrest by 48 hours in MM.1S and MOLP-8 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JQKD82 相关抗体:
体内研究
(In Vivo)

JQKD82 (50-75 mg/kg; i.p.; twice a day for 3 weeks) has anti-multiple myeloma activity[1].
JQKD82 displays an increase in H3K4me3 levels and results in a dramatic reduction of MYC immuno-staining in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice (bearing MOLP-8 TurboGFP-Luc cells)[1]
Dosage: 50 mg/kg, 75 mg/kg
Administration: i.p.; twice a day for 3 weeks
Result: Significantly reduced tumor burden.
分子量

500.63

Formula

C27H40N4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JQKD82 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JQKD822410512-38-6JADA82 PCK82JQKD 82JQKD-82JADA 82JADA-82PCK82PCK 82PCK-82Histone DemethylaseMM.1ScellsKDM5histoneH3lysinecancersInhibitorinhibitorinhibit

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