2. Neuronal Signaling
  3. Dopamine Transporter
  4. JJC8-091

JJC8-091 是一种有效的多巴胺转运蛋白 (dopamine transporter) 抑制剂，对 DAT 和 SERT 的 Ki 值分别为 230 和 97800 nM。JJC8-091 可用于研究兴奋剂使用障碍 (PSUD) 症。

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JJC8-091 Chemical Structure

JJC8-091 Chemical Structure

CAS No. : 1627576-76-4

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JJC8-091 相关抗体

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  • 生物活性

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生物活性

JJC8-091 is a potent dopamine transporter (DAT) inhibitor with Ki values of 230, 97800 nM for DAT, SERT, respectively. JJC8-091 has the potential for the research of psychostimulant use disorders (PSUD)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK-293T IC50
> 10000 nM
Compound: 9d, JJC8-091
Antagonist activity at DRD2 (unknown origin) expressed in HEK293T cells transfected with Galphai1-RLuc8 and gamma2-GFP10 assessed as inhibition of quinpirole-induced Gi1 activation pre-incubated with quinpirole for 10 mins before compound incubation for 1
Antagonist activity at DRD2 (unknown origin) expressed in HEK293T cells transfected with Galphai1-RLuc8 and gamma2-GFP10 assessed as inhibition of quinpirole-induced Gi1 activation pre-incubated with quinpirole for 10 mins before compound incubation for 1
[PMID: 27933960]
分子量

422.53

Formula

C22H28F2N2O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JJC8-091 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JJC8-0911627576-76-4Dopamine TransporterDATSLC6A3hERGpsychostimulant use disordersPSUDInhibitorinhibitorinhibit

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JJC8-091
目录号：
HY-163154
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