2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. JNJ 10181457 dihydrochloride

JNJ-10181457 是一种中性、强效、脑渗透和选择性的非咪唑类 H3 受体拮抗剂，可增加大鼠额叶皮质内 NE 和乙酰胆碱的浓度。JNJ-10181457 可用于神经学研究。

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JNJ 10181457 dihydrochloride Chemical Structure

JNJ 10181457 dihydrochloride Chemical Structure

CAS No. : 544707-20-2

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JNJ 10181457 dihydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Histamine Receptor 亚型特异性产品:

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNJ-10181457 is a neutral, potent, brain-penetrant and selective non-imidazole H3 antagonist which increases NE and ACh concentrations in rat frontal cortex. JNJ-10181457 can be used for neurological research[1].

IC50 & Target

H3 Receptor

 

体内研究
(In Vivo)

JNJ-10181457 (10 mg/kg, 腹腔注射, 60 min) 逆转 Imetit (HY-101173, 3 mg/kg, 皮下注射)-诱导的大鼠舔水行为与 Scopolamine (HY-N0296, 0.06 mg/kg, 腹腔注射)-诱导的 DNMTP 任务中错误反应的增加[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

385.37

Formula

C20H30Cl2N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNJ 10181457 dihydrochloride 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ 10181457544707-20-2JNJ10181457JNJ-10181457Histamine Receptorbrain-penetrantNEAChNeurological DiseaseInhibitorinhibitorinhibit

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目录号：
HY-107562
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