2. Vitamin D Related/Nuclear Receptor Immunology/Inflammation
  3. Progesterone Receptor Glucocorticoid Receptor Androgen Receptor Estrogen Receptor/ERR
  4. JNJ-1250132

JNJ-1250132  (Synonyms: RWJ-66826; RTI-6617-003)

目录号: HY-123163
产品使用指南

摩尔计算器

JNJ-1250132 (RWJ-66826) 是一种口服有效的类固醇孕酮受体 (PR) 拮抗剂，其 IC50 为 1.3 nM。JNJ-1250132 可在体外抑制受体与 DNA 的结合。 JNJ-1250132 是一种强效的竞争性抑制剂，可与人类糖皮质激素受体 (GR) (IC50=0.50 nM) 和大鼠雄激素受体 (AR) (IC50=5.6 nM) 结合，并且是与人类雌激素受体 (ER) (IC50 >3000 nM) 结合的弱抑制剂。

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JNJ-1250132 Chemical Structure

JNJ-1250132 Chemical Structure

CAS No. : 240805-96-3

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JNJ-1250132 相关抗体

Top Publications Citing Use of Products

查看 Estrogen Receptor/ERR 亚型特异性产品:

查看所有亚型
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNJ-1250132 (RWJ-66826) is an orally active and potent steroidal progesterone receptor (PR) antagonist, with an IC50 of 1.3 nM. JNJ-1250132 inhibits binding of the receptor to DNA in vitro. JNJ-1250132 is a potent competitive inhibitor of binding to the human glucocorticoid receptor (GR) (IC50=0.50 nM) and the rat androgen receptor (AR) (IC50=5.6 nM), and was a weak inhibitor of binding to human Estrogen receptor (ER) (IC50 >3000 nM)[1].

体外研究
(In Vitro)

JNJ-1250132 和 Mifepristone (HY-13683) 可抑制 R5020 (HY-119384) 刺激的细胞增殖，具有相似的半最大抑制浓度 (IC50 分别为 0.19 nM 和 0.17 nM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JNJ-1250132 相关抗体:
体内研究
(In Vivo)

JNJ-1250132 (10 mg/kg，口服，七天)可抑制 Dexamethasone (HY-14648) 诱导的退化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

515.68

Formula

C33H41NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNJ-1250132 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-1250132240805-96-3RWJ-66826 RTI-6617-003JNJ1250132JNJ 1250132RWJ66826RWJ 66826Progesterone ReceptorGlucocorticoid ReceptorAndrogen ReceptorEstrogen Receptor/ERRNR3C3T47D cellsbreast cancerinvolutionInhibitorinhibitorinhibit

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目录号：
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