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  4. JNJ-26076713

JNJ-26076713 是一种有效的口服活性 alpha V 整合素拮抗剂，对 alpha(V)beta(3) 和 alpha(V)beta(5) 的 IC50 值分别为 2.3 nM 和 6.3 nM。JNJ-26076713 抑制视网膜新生血管形成。

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JNJ-26076713 Chemical Structure

JNJ-26076713 Chemical Structure

CAS No. : 669076-03-3

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JNJ-26076713 相关抗体

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNJ-26076713 is a potent and orally active alpha V integrin antagonist with IC50 values of 2.3 nM and 6.3 nM for alpha(V)beta(3) and alpha(V)beta(5), respectively. JNJ-26076713 inhibits retinal neovascularization[1].

IC50 & Target[1]

αvβ3

2.3 nM (IC50)

αvβ5

6.3 nM (IC50)

体外研究
(In Vitro)

JNJ-26076713 (5-5000 nM) 以剂量依赖的方式抑制 FGF2 诱导的 HUVEC 迁移[1]。
JNJ-26076713 (0.1, 1, 和 10 μg) 以剂量依赖的方式抑制鸡胚绒毛尿囊膜 (CAM) 模型的血管生成[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JNJ-26076713 相关抗体:
体内研究
(In Vivo)

JNJ-26076713 (30-120 mg/kg; i.g.; 每天两次, 连续5天; 氧诱导视网膜病变 (OIR) 模型C57BL/6J 小鼠) 以剂量依赖的方式抑制视网膜新生血管[1]。
JNJ-26076713 (60 mg/kg; i.g.; 每天两次, 连续5天; 糖尿病 Long-Evans 大鼠) 抑制与糖尿病相关的视网膜血管通透性和白细胞瘀血的增加[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice with oxygen-induced retinopathy (OIR) model[1]
Dosage: 30, 60, and 120 mg/kg
Administration: Oral gavage, twice daily for 5 days
Result: Inhibited retinal neovascularization with 33, 43, and 67% inhibition of neovascularization at 30, 60, and 120 mg/kg, respectively.
Animal Model: Diabetic Long-Evans rats[1]
Dosage: 60 mg/kg
Administration: Oral gavage, twice daily for 5 days
Result: Reduced leukocyte adhesion with 48% and inhibited retinal vascular permeability in streptozotocin diabetic rats.
分子量

490.64

Formula

C29H38N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNJ-26076713 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

JNJ-26076713669076-03-3JNJ26076713JNJ 26076713Integrinretinal neovascularizationretinal vascular permeabilityHUVECFGF2chick chorioallantoic membraneInhibitorinhibitorinhibit

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