2. GPCR/G Protein
  3. Adenosine Receptor
  4. JNJ-40255293

JNJ-40255293 是一种高亲和的人 A 2A受体拮抗剂，其 Ki 值为 7.5 nM。JNJ-40255293 可用于帕金森病等神经退行性疾病研究。

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JNJ-40255293 Chemical Structure

JNJ-40255293 Chemical Structure

CAS No. : 1147271-25-7

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JNJ-40255293 相关抗体

Top Publications Citing Use of Products

查看 Adenosine Receptor 亚型特异性产品:

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNJ-40255293 is a high-affinity human A 2A receptor antagonist with a KiKi of 7.5 nM. JNJ-40255293 can be used in the research of neurodegenerative diseases such as Parkinson's disease[1].

体内研究
(In Vivo)

JNJ-40255293 (0.1-10 mg/kg, p.o.) 可以逆转氟哌啶醇 (HY-14538) 诱导的雄性 Balb/c 小鼠僵直症。在雄性 Wistar 大鼠中，JNJ-40255293 也可以剂量依赖性地逆转氟哌啶醇（0.63 mg/kg，皮下注射）诱导的强直性昏厥，增强主动觉醒，显着逆转利血平(HY-N0480)引起的运动活性缺陷[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

402.45

Formula

C23H22N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNJ-40255293 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-402552931147271-25-7JNJ40255293JNJ 40255293Adenosine ReceptorP1 receptorA2AParkinson's diseaseneurodegenerative diseaseInhibitorinhibitorinhibit

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产品名称：
JNJ-40255293
目录号：
HY-122105
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