2. GPCR/G Protein
  3. CRFR
  4. JTC-017

JTC-017 是一种特异性促肾上腺皮质激素释放激素受体1 (corticotropin-releasing hormone receptor 1) 拮抗剂，可减轻大鼠急性结直肠膨胀后海马去甲肾上腺素释放、内脏感知、促肾上腺皮质激素释放和焦虑。JTC-017阻断大鼠慢性结肠膨胀后应激诱导的结肠运动改变。

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JTC-017 Chemical Structure

JTC-017 Chemical Structure

CAS No. : 357330-77-9

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JTC-017 相关抗体

Top Publications Citing Use of Products

查看 CRFR 亚型特异性产品:

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CRFR1 CRFR2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. JTC-017 blocks stress-induced changes in colonic motility after chronic colorectal distention in rats[1].

分子量

490.40

Formula

C20H25Cl2N3O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JTC-017 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JTC-017357330-77-9JTC017JTC 017CRFRCorticotropin-releasing Factor ReceptorCRHRCorticotropin-releasing Hormone Receptor 1 AntagonistInhibitorinhibitorinhibit

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产品名称：
JTC-017
目录号：
HY-118821
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