2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. JTC-801 free base

JTC-801 free base 是一种具有选择性的 opioid receptor-like1 (ORL1) receptor 抑制剂，其 Ki 值为 8.2 nM。

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JTC-801 free base Chemical Structure

JTC-801 free base Chemical Structure

CAS No. : 244218-93-7

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JTC-801 free base 的其他形式现货产品:

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JTC-801 free base 相关抗体

Top Publications Citing Use of Products

    JTC-801 free base purchased from MCE. Usage Cited in: Oncol Lett. 2019 Feb;17(2):1939-1945.  [Abstract]

    Western blot analysis of proteins from Hep G2 cells treated with JTC‑801 for 24 h. The band intensities are quantified.

    JTC-801 free base purchased from MCE. Usage Cited in: Pharmazie. 2018 May 1;73(5):283-287.  [Abstract]

    Expression levels of proteins (BCL2, BAX and Active Caspase3) involved in the apoptotic pathway in the different SKOV3 groups, as detected by western blotting.

    JTC-801 free base purchased from MCE. Usage Cited in: J Recept Signal Transduct Res. 2018 Apr;38(2):133-140.  [Abstract]

    JTC-801 down-regulates BCL-2 expression, and up-regulates BAX, Caspase-3 expression in U2OS cells.

    查看 Opioid Receptor 亚型特异性产品:

    查看所有亚型
    μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    JTC-801 free base is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a Ki value of 8.2?nM.

    IC50 & Target

    Ki: 8.2?nM (ORL1)[2]
    细胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    CHO IC50
    1507 nM
    Compound: JTC-801
    Displacement of [3H]-naltrindole from human mu opioid receptor expressed in CHO cells after 2 hrs by scintillation counting
    Displacement of [3H]-naltrindole from human mu opioid receptor expressed in CHO cells after 2 hrs by scintillation counting
    		[PMID: 21330016]
    HEK293 IC50
    30 nM
    Compound: JTC-801
    Displacement of [125I]Tyr14-nociceptin from human NOP receptor expressed in human HEK293 cells after 2 hrs by scintillation counting
    Displacement of [125I]Tyr14-nociceptin from human NOP receptor expressed in human HEK293 cells after 2 hrs by scintillation counting
    		[PMID: 21330016]
    HEK293 IC50
    7512 nM
    Compound: JTC-801
    Displacement of [3H]-naltrindole from human kappa opioid receptor expressed in human HEK293 cells after 2 hrs by scintillation counting
    Displacement of [3H]-naltrindole from human kappa opioid receptor expressed in human HEK293 cells after 2 hrs by scintillation counting
    		[PMID: 21330016]
    分子量

    411.50

    Formula

    C26H25N3O2
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    JTC-801 free base 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    JTC-801244218-93-7JTC801JTC 801Opioid ReceptorInhibitorinhibitorinhibit

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    产品名称：
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    目录号：
    HY-13274A
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