2. Anti-infection
  3. HBV
  4. Junceellolide C

Junceellolide C 是一种 cccDNA 转录抑制剂。Junceellolide C 能抑制 HepAD38 细胞中 HBV DNA 的复制，且能显著降低细胞上清液中的 HBV RNA 水平，其 EC50 值分别为 5.19 和 3.52 μM。Junceellolide C 具有抗乙肝病毒活性。

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Junceellolide C Chemical Structure

Junceellolide C Chemical Structure

CAS No. : 121769-82-2

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Junceellolide C 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Junceellolide C is a transcription inhibitor of cccDNA. Junceellolide C inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA with EC50 values of 5.19, 3.52 μM respectively in HepAD38 cells. Junceellolide C is a potent anti-HBV agent[1].

IC50 & Target

EC50: 2.27 μM (HBV DNA replication), 3.52 μM (HBV RNA decrease) in HBeAg cells[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 CC50
> 100 μM
Compound: 27
Cytotoxicity against human HepG2 cells assessed as cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as cell viability incubated for 72 hrs by MTT assay
[PMID: 32690259]
体外研究
(In Vitro)

Junceellolide C (10 μM; 72 hours) inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA in HepAD38 cells with EC50 values of 2.27, 3.52 μM, respectively[1].
Junceellolide C (10 μM; 8 days) can capable to inhibit HBV cccDNA replenishment and also to induce the existed HBV cccDNA degradation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Junceellolide C 相关抗体:

Cell Viability Assay[1]

Cell Line: HepAD38 cells
Concentration: 10 μM
Incubation Time: 72 h, 8 days
Result: Inhibited cccDNA transcription.
分子量

540.99

Formula

C26H33ClO10
CAS 号
结构分类
初始来源

South China Sea gorgonian Dichotella gemmacea
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Junceellolide C 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Junceellolide C121769-82-2HBVHepatitis B viruscccDNAHBV DNA replicationanti-HBVHepAD38Inhibitorinhibitorinhibit

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