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  4. K-252d

K-252d 是一种在诺卡氏菌中发现的吲哚咔唑生物碱。它是一种 PKC 抑制剂，可抑制从大鼠脑中分离的 PKC（IC50=350 nM）。它还可抑制从牛心脏中分离的钙和钙调蛋白依赖性磷酸二酯酶（IC50=46.2 μM）。

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K-252d Chemical Structure

K-252d Chemical Structure

CAS No. : 105114-22-5

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K-252d 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

K-252d is an indolocarbazole alkaloid found in Nocardiopsis. It is a PKC inhibitor that inhibits PKC isolated from rat brain (IC50=350 nM). It also inhibits calcium- and calmodulin-dependent phosphodiesterase isolated from bovine heart (IC50=46.2 μM).

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
9 μM
Compound: 6; K252d
Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as decrease in cell viability after 48 hrs by MTT assay
[PMID: 30106291]
K562 IC50
> 100 μM
Compound: 6; K252d
Cytotoxicity against human K562 cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as decrease in cell viability after 48 hrs by MTT assay
[PMID: 30106291]
L02 IC50
73.8 μM
Compound: 6; K252d
Cytotoxicity against human LO2 cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human LO2 cells assessed as decrease in cell viability after 48 hrs by MTT assay
[PMID: 30106291]
分子量

457.48

Formula

C26H23N3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

K-252d 相关分类

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Keywords:

K-252d105114-22-5OthersInhibitorinhibitorinhibit

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