2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. K-Opioid receptor agonist-1

K-Opioid receptor agonist-1 (Compound 5a) 是 κ-阿片受体的激动剂，Ki 为 0.25 nM，EC50 为 2 nM。K-Opioid receptor agonist-1 可穿透血脑屏障 (BBB) (脑/血浆比率为 0.50-0.65)。K-Opioid receptor agonist-1 在由 Arachidonic acid (HY-109590) 或 oxazolidinone 诱发的皮炎模型中表现出抗炎活性。

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K-Opioid receptor agonist-1 Chemical Structure

K-Opioid receptor agonist-1 Chemical Structure

CAS No. : 1816990-29-0

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K-Opioid receptor agonist-1 相关抗体

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查看 Opioid Receptor 亚型特异性产品:

查看所有亚型
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

K-Opioid receptor agonist-1 (Compound 5a) is an agonist for κ-Opioid receptor with Ki of 0.25 nM and EC50 of 2 nM. K-Opioid receptor agonist-1 is blood brain barrier (BBB) penetrate (brain/plasma ratios of 0.50 to 0.65). K-Opioid receptor agonist-1 exhibits anti-inflammatory activity in dermatitis models induced by Arachidonic acid (HY-109590) or oxazolidinone[1].

IC50 & Target

κ Opioid Receptor/KOR

0.25 nM (Ki)

μ Opioid Receptor/MOR

43 nM (Ki)

δ Opioid Receptor/DOR

58 nM (Ki)

分子量

454.39

Formula

C22H29Cl2N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

K-Opioid receptor agonist-1 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K-Opioid receptor agonist-11816990-29-0Opioid ReceptorLethargyhunchedear swellinghypersensitivity CD4+CD8+HEK293dermatitisWIstar ratBALB/c mouseICR mouseInhibitorinhibitorinhibit

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