2. PROTAC
  3. Target Protein Ligand-Linker Conjugates
  4. K-Ras ligand-Linker Conjugate 2

K-Ras ligand-Linker Conjugate 2 

目录号: HY-129776
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摩尔计算器

K-Ras ligand-Linker Conjugate 2 包含靶蛋白 K-Ras 配体和 PROTAC linker，可募集 E3 连接酶 (如 VHL，CRBN，MDM2 和 IAP 等类型)。K-Ras ligand-Linker Conjugate 2 可用于合成 PROTAC K-Ras Degrader-1 (HY-129523)，PROTAC K-Ras Degrader-1 是一种有效的 PROTAC K-Ras 降解剂，在 SW1573 中对 K-Ras 的降解率 ≥70%。

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K-Ras ligand-Linker Conjugate 2 Chemical Structure

K-Ras ligand-Linker Conjugate 2 Chemical Structure

CAS No. : 2741300-61-6

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K-Ras ligand-Linker Conjugate 2 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

K-Ras ligand-Linker Conjugate 2 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 2 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

K-Ras ligand-Linker Conjugate 2 相关抗体:
分子量

822.99

Formula

C45H58N8O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

K-Ras ligand-Linker Conjugate 2 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

K-Ras ligand-Linker Conjugate 22741300-61-6Target Protein Ligand-Linker ConjugatesK-RasE3ligasesVHLCRBNMDM2IAPproteindegradationPROTACDegrader-1Inhibitorinhibitorinhibit

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