2. Protein Tyrosine Kinase/RTK MAPK/ERK Pathway Apoptosis
  3. FLT3 MNK Apoptosis
  4. K783-0308

K783-0308 是一种有效且选择性的 FLT3 和 MNK2 双重抑制剂，IC50 值分别为 680 和 406 nM。 K783-0308 抑制 MOLM-13 (IC50=10.5 µM) 和 MV-4-11 (IC50=10.4 µM) 细胞的生长。K783-0308 促进急性髓性白血病 (AML) 细胞的凋亡 (apoptosis) 并使细胞周期停滞在 G0/G1 期。

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K783-0308 Chemical Structure

K783-0308 Chemical Structure

CAS No. : 422554-29-8

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K783-0308 相关抗体

Top Publications Citing Use of Products

查看 MNK 亚型特异性产品:

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MNK1 MNK2 MNK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

K783-0308 is a potent and selective dual inhibitor of FLT3 and MNK2 with IC50 values of 680 and 406 nM, respectively. K783-0308 inhibits the growth of MOLM-13 (IC50=10.5 µM) and MV-4-11 (IC50=10.4 µM) cells. K783-0308 promotes acute myeloid leukemia (AML) cell apoptosis and cell cycle arrests in the G0/G1 phase[1].

IC50 & Target

MNK2

406 nM (IC50)

体外研究
(In Vitro)

K783-0308 (MOLM-13, MV-4-11 cells) shows cytotoxic effect against MOLM-13 (IC50=10.5 µM) and MV-4-11 (IC50=10.4 µM) cells[1].
K783-0308 (1, 3, 10, 30 µM) promotes AML cell apoptosis and cell cycle arrests in the G0/G1 phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

K783-0308 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: MOLM-13, MV-4-11 cells (RPMI-1640 supplemented with streptomycin (100 µg/mL)/penicillin (100 U/mL)/ amphotericin B (0.25 µg/mL))
Concentration: 1, 3, 10, 30 µM
Incubation Time: 48 h, 72 h
Result: Promotes AML cell apoptosis and cell cycle arrested in the G0/G1 phase.
分子量

333.43

Formula

C21H23N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

K783-0308 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K783-0308422554-29-8FLT3MNKApoptosisCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Mitogen activated protein kinase interacting kinaseMAP kinase interacting kinaseMAPK interacting kinaseacute myeloid leukemia (AML)G0/G1 phaseapoptosisMOLM-13 cellsMV-4-11 cellsselectiveInhibitorinhibitorinhibit

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K783-0308
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