Kaolin  (Synonyms: 水合硅酸铝, 瓷土, 碱式硅酸铝)

Kaolin is a family of kaolinitic clays, which is found in the earth's crust. Kaolin alleviates the toxicity of graphene oxide for mammalian cells. Kaolin can be utilized in industrial, cosmetic and medical fields, excipient^{[1][2][3][4][5]}.

Kaolin (50, 100 μg/mL, 72 小时) 与 graphene oxide (50, 100 μg/mL, 72 小时) 联合可降低 HCT-116 细胞中石墨烯的毒性^[3]。
Kaolin (100 μg/mL, 30-180 分钟) 诱导 RAW264 细胞产生细胞间 ROS^[4]。
Kaolin (100 μg/mL, 24 小时) 增加 RAW264 细胞中白细胞介素-1β (IL-1β) 和肿瘤坏死因子-α (TNF-α) 浓度^[4]。
Kaolin (100 μg/mL, 60 分钟) 可增加 A549 细胞与 RAW264 细胞共培养的 DNA 损伤^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Kaolin (0.05 和 0.2 mg，气管内灌注，持续 3 小时和 24 小时) 诱导小鼠肺 DNA 损伤^[4]。
Kaolin (5.0/0.1 mg/mL 溶于 0.15 M NaCl，气管内接种，持续 24 小时-210 天) 可刺激小鼠早期急性炎症反应，增加病灶区成纤维细胞活性^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

258.16

1332-58-7

固体

White to off-white

水合硅酸铝, 瓷土, 碱式硅酸铝

Room temperature in continental US; may vary elsewhere.

Store at room temperature 3 years

• [1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  [Content Brief]

  [2]. Zhang Z H, et al. Geopolymer from kaolin in China: An overview[J]. Applied Clay Science, 2016, 119: 31-41.

  [3]. Rozhina E, et al. Kaolin alleviates the toxicity of graphene oxide for mammalian cells. Medchemcomm. 2019 Jun 10;10(8):1457-1464.  [Content Brief]

  [4]. Kato T, et al. Effect of physicochemical character differences on the genotoxic potency of kaolin. Genes Environ. 2017 May 1;39:12.  [Content Brief]

  [5]. Sahu AP, Shanker R, Zaidi SH. Pulmonary response to kaolin, mica and talc in mice. Exp Pathol (Jena). 1978;16(1-6):276-82.  [Content Brief]