2. GPCR/G Protein Neuronal Signaling
  3. GPR55
  4. KLS-13019

KLS-13019 是一种具有口服活性的 GPR55 受体拮抗剂，结构上属于大麻二酚 (CBD) 类似物，可在大鼠中可以以剂量依赖的方式预防和逆转化疗诱导的外周神经疼痛 (CIPN)。

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KLS-13019 Chemical Structure

KLS-13019 Chemical Structure

CAS No. : 1801243-39-9

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KLS-13019 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KLS-13019 is an orally active GPR55 receptor antagonist and a structural analogue of cannabidiol (CBD). It can prevent and reverse chemotherapy-induced peripheral neuropathy (CIPN) in a dose-dependent manner in rats[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Hippocampal neurone EC50
0.04 μM
Compound: 16; KLS-13019
Neuroprotective activity in rat hippocampal neurons assessed as protection against ammonium acetate induced cell death by measuring neuronal viability after 5 hrs by carboxyfluorescein diacetate dye based fluorimetric analysis
Neuroprotective activity in rat hippocampal neurons assessed as protection against ammonium acetate induced cell death by measuring neuronal viability after 5 hrs by carboxyfluorescein diacetate dye based fluorimetric analysis
[PMID: 27096053]
Hippocampal neurone EC50
0.04 μM
Compound: 16; KLS-13019
Neuroprotective activity in rat hippocampal neurons assessed as protection against ammonium acetate induced cell death after 5 hrs by propidium iodide staining based fluorimetric analysis
Neuroprotective activity in rat hippocampal neurons assessed as protection against ammonium acetate induced cell death after 5 hrs by propidium iodide staining based fluorimetric analysis
[PMID: 27096053]
Hippocampal neurone EC50
0.05 μM
Compound: 16; KLS-13019
Neuroprotective activity in rat hippocampal neurons assessed as protection against ethanol induced cell death after 5 hrs by propidium iodide staining based fluorimetric analysis
Neuroprotective activity in rat hippocampal neurons assessed as protection against ethanol induced cell death after 5 hrs by propidium iodide staining based fluorimetric analysis
[PMID: 27096053]
Hippocampal neurone EC50
0.08 μM
Compound: 16; KLS-13019
Neuroprotective activity in rat hippocampal neurons assessed as protection against ethanol induced cell death by measuring neuronal viability after 5 hrs by carboxyfluorescein diacetate dye based fluorimetric analysis
Neuroprotective activity in rat hippocampal neurons assessed as protection against ethanol induced cell death by measuring neuronal viability after 5 hrs by carboxyfluorescein diacetate dye based fluorimetric analysis
[PMID: 27096053]
分子量

355.47

Formula

C22H29NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KLS-13019 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KLS-130191801243-39-9KLS13019KLS 13019GPR55G protein-coupled receptor 55Chemotherapy-induced peripheral neuropathyInhibitorinhibitorinhibit

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产品名称：
KLS-13019
目录号：
HY-123239
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