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  4. KMS88009

KMS88009是一种强效的小分子试剂，能够直接干扰淀粉样β（amyloid-b）寡聚体的形成，从而在预防性使用时保持认知行为，在抑制性使用时逆转认知行为的下降。KMS88009在阿尔茨海默病症状出现前后的口服给药，显著减少了淀粉样β寡聚体的组装，并在APP/PS1双转基因小鼠模型中改善了认知行为。这种独特的双重作用模式表明，KMS88009可能是抑制阿尔茨海默病的强大 therapeutic candidate。在一项评估中，研究了这种抗淀粉样变性的小分子KMS88009的物理化学性质、药代动力学和毒性，以及行为测试后的post-mortem analysis of APP/PS1 TG小鼠。

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KMS88009 Chemical Structure

KMS88009 Chemical Structure

CAS No. : 1089681-42-4

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KMS88009 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KMS88009 is a potent small molecule that directly interferes with the formation of amyloid-β oligomers, thereby preserving cognitive behavior when used preventively and reversing cognitive behavior decline when used therapeutically. Oral administration of KMS88009 around the onset of Alzheimer's disease symptoms significantly reduced the assembly of amyloid-β oligomers and improved cognitive behavior in the APP/PS1 double transgenic mouse model. This unique dual mode of action suggests that KMS88009 may be a powerful therapeutic candidate for the treatment of Alzheimer's disease. In an evaluation, the physicochemical properties, pharmacokinetics and toxicity of this anti-amyloidogenic small molecule KMS88009 were studied, as well as post-mortem analysis of APP/PS1 TG mice after behavioral testing.

分子量

293.36

Formula

C19H19NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KMS88009 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KMS880091089681-42-4KMS 88009KMS-88009OthersInhibitorinhibitorinhibit

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产品名称：
KMS88009
目录号：
HY-118243
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