Kocurin  (Synonyms: PM181104; Baringolin)

Kocurin (PM181104) is a thiazolyl cyclic-peptide antibiotic. Kocurin inhibits bacterial growth by impeding bacterial protein biosynthesis during the translation phase. Kocurin has strong inhibitory activity against gram-positive bacteria, but no activity against fungi and Gram-negative bacteria^[1].

Kocurin (24 小时) 抑制金黄色葡萄球菌，MIC 范围为 0.008 至 2.048 μg/mL，MIC₉₀ 值为 0.064 μg/mL^[1]。
Kocurin (24 小时) 抑制表皮葡萄球菌，MIC 范围为 0.008 至 1.024 μg/mL，MIC₉₀ 值为 0.128 μg/mL^[1]。
Kocurin (24 小时) 抑制 VRE 和 VSE 菌株，MIC 范围为 0.004 至 1.024 μg/mL，MIC₉₀ 值为 0.016 μg/mL^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Kocurin (1.25-10 mg/kg；静脉注射；单剂量) 在 BALB/c 小鼠败血症模型中，对 MRSA 的 100% 有效剂量 (ED₁₀₀) 值为 2.5 和 5.0 mg/kg，对 VRE 的 ED₁₀₀ 值为 10.0 mg/kg^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1515.70

C₆₉H₆₆N₁₈O₁₃S₅

1374772-61-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mahajan G, et al. In vitro and in vivo activities of antibiotic PM181104. Antimicrob Agents Chemother. 2013 Nov;57(11):5315-9.  [Content Brief]