2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. KOR/DOR agonist 1

KOR/DOR agonist 2 是一种 KOR 和 DOR 阿片受体激动剂，Ki 值分别为 0.14 nM 和 0.93 nM。KOR/DOR agonist 2 表现出显著的抗伤害作用。KOR/DOR agonist 2 可穿透血脑屏障。

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KOR/DOR agonist 1 Chemical Structure

KOR/DOR agonist 1 Chemical Structure

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KOR/DOR agonist 1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KOR/DOR agonist 2 is a KOR and DOR opioid receptors agonist with Ki values of 0.14 nM, and 0.93 nM, respectively. KOR/DOR agonist 2 shows significant antinociceptive effects. KOR/DOR agonist 2 penetrates the blood-brain barrier[1].

IC50 & Target[1]

κ Opioid Receptor/KOR

0.14 nM (Ki)

δ Opioid Receptor/DOR

0.2 nM (Ki)

μ Opioid Receptor/MOR

0.93 nM (Ki)

体外研究
(In Vitro)

KOR/DOR agonist 2（化合物 21）与 MOR 的结合力为亚纳摩尔，Ki 值为 0.20 nM[1]。
在 [35S]-GTPγS 结合试验中，KOR/DOR agonist 2 在 KOR、MOR 和 DOR 处表现出功能活性，EC50 值分别为 0.04 nM、0.58 nM、1.28 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KOR/DOR agonist 1 相关抗体:
体内研究
(In Vivo)

KOR/DOR agonist 2（0.1 mg/kg；皮下注射；一次）在温水尾浸试验中产生显著的抗伤害作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss Webster mice (6-8 week-old)[1]
Dosage: 0.1 mg/kg
Administration: Subcutaneous injection; once
Result: Showed significant antinociceptive effects.
分子量

476.56

Formula

C28H32N2O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KOR/DOR agonist 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KOR/DOR agonist 1Opioid ReceptorKOR/DOR agonistantinociceptive effectsblood-brain barrieInhibitorinhibitorinhibit

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