2. Protein Tyrosine Kinase/RTK Neuronal Signaling Apoptosis Autophagy
  3. c-Met/HGFR FLT3 Trk Receptor Apoptosis Autophagy
  4. KRC-108

KRC-108 是一种具有口服活性的，氨基吡啶类多激酶抑制剂，对 c-Met、c-Met M1250T、c-Met Y1230D、Ron、Flt3 和 TrkA 的 IC50 分别为 80 nM、23 nM、3 nM、70 nM、30 nM、39 nM。KRC-108 可诱导细胞周期停滞、凋亡和自噬。KRC-108 在无胸腺 BALB/c nu/nu 小鼠的 HT29 结直肠癌、NCI-H441 肺癌异种移植模型中表现出抗肿瘤活性。

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KRC-108 Chemical Structure

KRC-108 Chemical Structure

CAS No. : 1146944-35-5

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KRC-108 相关抗体

Top Publications Citing Use of Products

查看 Trk Receptor 亚型特异性产品:

查看所有亚型
TrkA TrkB TrkC Trk

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KRC-108, an aminopyridine, is an orally active multiple kinase inhibitor with IC50s of 80 nM, 23 nM, 3 nM, 70 nM, 30 nM, 39 nM for c-Met, c-Met M1250T, c-Met Y1230D, Ron, Flt3 and TrkA, respectively. KRC-108 induces cell cycle arrest, apoptotic cell death, and autophagy. KRC-108 exhibits anti-tumor activity in vivo in HT29 colorectal cancer, NCI-H441 lung cancer xenograft models in athymic BALB/c nu/nu mice[1].

IC50 & Target[1]

c-Met

80 nM (IC50)

c-Met M1250T

23 nM (IC50)

c-Met Y1230D

3 nM (IC50)

Ron

70 nM (IC50)

Flt3

30 nM (IC50)

TrkA

39 nM (IC50)

ALK

780 nM (IC50)

VEGFR2

1660 nM (IC50)

分子量

360.41

Formula

C20H20N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KRC-108 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRC-1081146944-35-5KRC108KRC 108c-Met/HGFRFLT3Trk ReceptorApoptosisAutophagyCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Tropomyosin related kinase receptor aminopyridineorallyc-Met M1250Tc-Met Y1230Dcycle arrestHT29colorectal cancerNCI-H441lung cancerInhibitorinhibitorinhibit

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