2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Kv7.2/Kv7.3 agonist 1

Kv7.2/Kv7.3 agonist 1 (Compound 16) 是口服有效的 KV7.2/7.3 通道 (KV7.2/7.3 channel/KCNQ2/3) 激动剂，EC50 为 1.03 μM。Kv7.2/Kv7.3 agonist 1 在小鼠慢性压迫性损伤 (CCI) 模型和小鼠 Streptozotocin (HY-13753) 诱发的糖尿病周围神经性疼痛 (DPNP) 模型中表现出镇痛作用，ED50 分别为 12.02 和 9.63 mg/kg。

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Kv7.2/Kv7.3 agonist 1 Chemical Structure

Kv7.2/Kv7.3 agonist 1 Chemical Structure

CAS No. : 2315450-35-0

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Kv7.2/Kv7.3 agonist 1 相关抗体

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生物活性

Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally active agonist for KV7.2/7.3 channel (KCNQ2/3) with an EC50 of 1.03 μM. Kv7.2/Kv7.3 agonist 1 exhibits analgesic efficacy in mice chronic constriction injury (CCI) model and mice Streptozotocin (HY-13753)-induced diabetic peripheral neuropathic pain (DPNP) model, with ED50 of 12.02 and 9.63 mg/kg[1].

IC50 & Target

KCNQ2/Q3

1.03 μM (EC50)

分子量

275.28

Formula

C14H14FN3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Kv7.2/Kv7.3 agonist 1 相关分类

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Keywords:

Kv7.2/Kv7.3 agonist 12315450-35-0Potassium ChannelKcsAorally activeanalgesicKM mouseInhibitorinhibitorinhibit

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