2. Immunology/Inflammation
  3. Complement System
  4. L-156602

L-156602  (Synonyms: Antibiotic L 156602; PD 124966)

目录号: HY-16384
产品使用指南

摩尔计算器

L-156602 是一种 C5a receptor 拮抗剂。L-156602 在小鼠炎症模型中显著抑制炎症以及单核细胞和中性粒细胞向浸润部位的迁移。L-156602 抑制迟发型超敏反应 (delayed-type hypersensitivity, DTH) 的传出期。

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L-156602 Chemical Structure

L-156602 Chemical Structure

CAS No. : 125228-51-5

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规格 价格 是否有货 数量
500 μg ￥4730
3 - 4 周

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Customer Review

L-156602 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-156602 is a C5a receptor antagonist. L-156602 inhibits inflammation, and the migration of monocytes and neutrophils to the infiltrating site in mouse inflammatory models. L-156602 suppresses the efferent phase of delayed-type hypersensitivity (DTH)[1][2].

IC50 & Target

C5a receptor[1][2]
体内研究
(In Vivo)

L-156602 (0.1-0.5 mg/kg， i.p.， 每天一次连续 3 天) 显著抑制 Concanavalin A (HY-P2149) 诱导的 CDF1 小鼠和Muramyl dipeptide (MDP) (HY-127090) 诱导的 BALB/c 小鼠中的炎症[1][2]。
L-156602 (0.2-0.5 mg/kg， i.p.) 抑制 PCI 诱导的 DBA/1 小鼠炎症中单核白细胞和中性粒细胞向炎症部位的浸润[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Concanavalin A-induced inflammation of CDF1 mice[1][2]
Dosage: 0.1, 0.5 mg/kg, once daily for 3 days
Administration: Intraperitoneal injection (i.p.)
Result: Suppressed the swelling completely after 4 h at 0.1 mg/kg, and the effect was still statistical after 24 h at 0.5 mg/kg.
Reduced the number of migrated leukocytes.
Suppressed the migration of neutrophils, macrophages and lymphocytes non-specifically.
Animal Model: MDP-induced acute joint inflammation of BALB/c mice[1]
Dosage: 0.25, 0.5 mg/kg, once daily for 3 days
Administration: Intraperitoneal injection (i.p.)
Result: Suppressed adjuvant arthritis although a slight reduction of body weight at the dose of 0.5 mg/kg after 24 h.
Animal Model: 0.5% PCI-induced inflammation of DBA/1 mice[2]
Dosage: 0.2, 0.5 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Suppressed ear swelling significantly and the infiltration of mononuclear leukocytes and neutrophils into the site of inflammation.
Animal Model: 5% PCI-induced inflammation of DBA/1 mice[2]
Dosage: 0.4 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Suppressed the infiltration of mononuclear leukocytes and neutrophils into the site of inflammation non-specifically.
分子量

840.96

Formula

C38H64N8O13
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

L-156602 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-156602125228-51-5Antibiotic L 156602 PD 124966L156602L 156602Antibiotic L156602Antibiotic L-156602PD124966PD 124966PD-124966Complement Systemconcanavalin AMDP or PCI induced mouse modelsinflammationdelayed-type hypersensitivity (DTH)Inhibitorinhibitorinhibit

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