2. Anti-infection
  3. HIV
  4. L 738372

L-738372 是一种非竞争性 HIV-1 逆转录酶 (RT) 的可逆抑制剂，针对 dTTP 的抑制常数 (Ki)为 140 nM。L-738,372 与任何核苷类似物 (如阿基多胸苷三磷酸、去氧肌苷三磷酸或去氧胞苷三磷酸) 组合时，表现出协同抑制 RT 活性。L-738372 对阿基多胸苷耐药型 RT (D67N、K70R、T215Y、K219Q) 的抑制效力是野生型 RT 的 2-3 倍。L-738372 有望用于抗 HIV 病毒领域的研究。

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L 738372 Chemical Structure

L 738372 Chemical Structure

CAS No. : 159565-60-3

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L 738372 相关抗体

Top Publications Citing Use of Products

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HIV HIV-1 HIV-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-738372 is a non-competitive reversible inhibitor of HIV-1 reverse transcriptase (RT) with an inhibition constant (Ki) of 140 nM against dTTP. When combined with any nucleoside analogs (such as azidothymidine triphosphate, didexoyinosine triphosphate, or didexoycytidine triphosphate), L-738372 exhibits synergistic inhibition of RT activity. L-738372 has 2-3 times more inhibitory potency against the azidothymidine-resistant RT (D67N, K70R, T215Y, K219Q) compared to the wild-type RT. L-738372 holds promise for research in the field of HIV virus treatment[1].

IC50 & Target

HIV-1

 

分子量

289.33

Formula

C18H15N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

L 738372 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L 738372159565-60-3L738372L-738372HIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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