1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. L-Aspartic acid-13C4

L-Aspartic acid-13C4  (Synonyms: L-天门冬氨酸 13C4)

目录号: HY-N0666S4 纯度: 98.30%
COA 产品使用指南 技术支持

L-Aspartic acid-13C4 是带有 13C 标记的 L-Aspartic acid。L-Aspartic acid 是一种氨基酸,被证明是一种结肠特异性活性分子输送的前体活性分子。

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L-Aspartic acid-<sup>13</sup>C<sub>4</sub> Chemical Structure

L-Aspartic acid-13C4 Chemical Structure

CAS No. : 55443-54-4

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5 mg ¥1530
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10 mg ¥2430
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25 mg ¥4950
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Other Forms of L-Aspartic acid-13C4:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-Aspartic acid-13C4 is the 13C-labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
15 μM
Compound: 5960
Substrate uptake by the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A3 cells
Substrate uptake by the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A3 cells
10.5281/zenodo.6782621
HEK293 EC50
398 μM
Compound: L-asp
Inhibition of the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by L-glutamate uptake in HEK-293 JumpIN-SLC1A3 cells
Inhibition of the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by L-glutamate uptake in HEK-293 JumpIN-SLC1A3 cells
[PMID: 35677430]
体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

137.07

Formula

13C4H7NO4

CAS 号
非标记 CAS
性状

固体

颜色

White to off-white

中文名称

L-天门冬氨酸 13C4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验: 

1 M NaOH 中的溶解度 : 100 mg/mL (729.55 mM; adjust pH to 12 with 1 M NaOH)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 7.2955 mL 36.4777 mL 72.9554 mL
5 mM 1.4591 mL 7.2955 mL 14.5911 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.30%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
1 M NaOH 1 mM 7.2955 mL 36.4777 mL 72.9554 mL 182.3886 mL
5 mM 1.4591 mL 7.2955 mL 14.5911 mL 36.4777 mL
10 mM 0.7296 mL 3.6478 mL 7.2955 mL 18.2389 mL
15 mM 0.4864 mL 2.4318 mL 4.8637 mL 12.1592 mL
20 mM 0.3648 mL 1.8239 mL 3.6478 mL 9.1194 mL
25 mM 0.2918 mL 1.4591 mL 2.9182 mL 7.2955 mL
30 mM 0.2432 mL 1.2159 mL 2.4318 mL 6.0796 mL
40 mM 0.1824 mL 0.9119 mL 1.8239 mL 4.5597 mL
50 mM 0.1459 mL 0.7296 mL 1.4591 mL 3.6478 mL
60 mM 0.1216 mL 0.6080 mL 1.2159 mL 3.0398 mL
80 mM 0.0912 mL 0.4560 mL 0.9119 mL 2.2799 mL
100 mM 0.0730 mL 0.3648 mL 0.7296 mL 1.8239 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
L-Aspartic acid-13C4
目录号:
HY-N0666S4
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