L803-mts  (Synonyms: Myristoylated L 803; GSK-3β Inhibitor XIII)

L803-mts (Myristoylated L 803) is a selective and substrate-competitive GSK-3 peptide inhibitor (IC₅₀: 40 μM). L803-mts also reduces Aβ deposits and ameliorates cognitive deficits in 5XFAD mice. L803-mts shows antidepressive effect in the forced swimming test^[1][2].

1464.64

C₆₆H₁₁₀N₁₅O₂₀P

1043881-55-5

{Myr}-Gly-Lys-Glu-Ala-Pro-Pro-Ala-Pro-Pro-Gln-{Ser(PO3H)}-Pro-NH2

{Myr}-GKEAPPAPPQ-{Ser(PO3H)}-P-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kaidanovich-Beilin O, et al. Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus. Biol Psychiatry. 2004 Apr 15;55(8):781-4.  [Content Brief]

  [2]. Avrahami L, et al. Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies. J Biol Chem. 2013 Jan 11;288(2):1295-306.  [Content Brief]