2. Anti-infection
  3. Fungal
  4. Laccase-IN-3

Laccase-IN-3 (Compound 2b) 是一种 laccase 抑制剂 (IC50 = 1.02= μM)，具有显著的抗真菌活性。对 Botryosphaeria dothidea 具有优越的抑制效果 (EC50 = 0.17 mg/L)。Laccase-IN-3 通过与漆酶的活性中心结合，有效地阻断了其催化功能。Laccase-IN-3 还可以破坏病原体的细胞膜完整性并增加 ROS。

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Laccase-IN-3 Chemical Structure

Laccase-IN-3 Chemical Structure

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Laccase-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Laccase-IN-3 (Compound 2b) is a laccase inhibitor (IC50 = 1.02= μM) with significant antifungal activity. Laccase-IN-3 shows superior inhibitory effect on Botryosphaeria dothidea (EC50 = 0.17 mg/L). Laccase-IN-3 effectively blocks the catalytic function of laccase by binding to its active center. Laccase-IN-3 also disrupts pathogen cell membrane integrity and increases ROS[1].

体外研究
(In Vitro)

Laccase-IN-3 (25 mg/L) 对真菌活性的抑制率分别为 98.2% (B. dothidea), 92% (S. sclerotiorum), 93.9 % (F. graminearum), 53.1 % (B. cinerea), 59.9 % (P. capsici), 22.0 % (P. infestans), 81.5 % (P. nicotianae)[1]。
Laccase-IN-3 对各种真菌的 ECsub>50 分别为 0.17 mg/L (B. dothidea), 2.55 mg/L (S. sclerotiorum), 2.03 mg/L (F. graminearum)[1]。
Laccase-IN-3 (0.79-6.25 mg/L;) 通过破坏 B. dothidea 菌丝的形态来抑制真菌生长[1]。
Laccase-IN-3 (10-25 mg/L; 120 min) 破坏了 B. dothidea 菌丝体细胞膜的完整性，并增加了细胞膜透性。降低了细胞外 pH 值,破坏细胞内环境的稳定性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Laccase-IN-3 相关抗体:
体内研究
(In Vivo)

Laccase-IN-3 (100,200 mg/L; 6 天) 展现出对感染 B. dothidea 的 apple 显著的保护活性（92.6% 和 86.8%）和治疗活性（85.0% 和 78.9%），均优于 Boscalid (HY-119976)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

246.28

Formula

C14H15FN2O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Laccase-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Laccase-IN-3FungalLaccase inhibitorAntifungal agentsplant protectionCell membrane disruptorReactive oxygen generation agentBotryosphaeria dothideaInhibitorinhibitorinhibit

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